H0ZCF8 · H0ZCF8_TAEGU
- Proteinalcohol dehydrogenase (NADP(+))
- GeneAKR1A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids327 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- S-nitroso-CoA + NADPH + H+ = sulfinamide-CoA + NADP+This reaction proceeds in the forward direction.
- S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 52 | Proton donor | ||||
Sequence: Y | ||||||
Site | 82 | Lowers pKa of active site Tyr | ||||
Sequence: K | ||||||
Binding site | 115 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cytosol | |
Cellular Component | synapse | |
Molecular Function | aldose reductase (NADPH) activity | |
Molecular Function | glucuronolactone reductase activity | |
Molecular Function | L-glucuronate reductase activity | |
Molecular Function | S-nitrosoglutathione reductase (NADH) activity | |
Biological Process | aldehyde catabolic process | |
Biological Process | cellular detoxification of aldehyde | |
Biological Process | D-glucuronate catabolic process to D-xylulose 5-phosphate | |
Biological Process | daunorubicin metabolic process | |
Biological Process | doxorubicin metabolic process | |
Biological Process | L-ascorbic acid biosynthetic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namealcohol dehydrogenase (NADP(+))
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Estrildidae > Estrildinae > Taeniopygia
Accessions
- Primary accessionH0ZCF8
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-295 | NADP-dependent oxidoreductase | ||||
Sequence: GLGTWKSDRGQVKEAVKHALSVGYRHIDCAAAYSNEAEIGDAFQECVGPNKVIKREDLFVTSKLWNTKHHPEDVEPALRKTLGDMKLDYLDLYLMHWPHAFERGDNLFPKNPDNTMRYDYIDYKDTWKAMEKLVEKGLVKAIGLSNFNSRQIDDVLSVATVKPAVLQVECHPYLAQNELIAHCQKRGLVVTAYSPLGSPDRMWKHPDEPVLLEEPGVKKIAEKYSKSPAQIVLRWQVQRKVVVIPKSVTPARIQQNLQVFDFSLTEEEMSHIGSLN |
Sequence similarities
Belongs to the aldo/keto reductase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length327
- Mass (Da)37,274
- Last updated2012-02-22 v1
- Checksum9D398CB27C58967F
Keywords
- Technical term