G7YP97 · G7YP97_CLOSI

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site845Nucleophile
Active site929
Active site931

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionamino acid binding
Molecular Functionaspartate carbamoyltransferase activity
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functiondihydroorotase activity
Molecular Functionmetal ion binding
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processcitrulline biosynthetic process
Biological Processglutamine metabolic process
Biological ProcessUTP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Submitted names
    • Carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase

Gene names

    • ORF names
      CLF_105410

Organism names

  • Taxonomic identifier
  • Strain
    • Henan
  • Taxonomic lineage
    Eukaryota > Metazoa > Spiralia > Lophotrochozoa > Platyhelminthes > Trematoda > Digenea > Opisthorchiida > Opisthorchiata > Opisthorchiidae > Clonorchis

Accessions

  • Primary accession
    G7YP97

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region172-209Disordered
Compositional bias192-209Polar residues
Region232-267Disordered
Compositional bias239-257Polar residues
Domain1131-1323ATP-grasp
Domain1717-1908ATP-grasp
Domain2004-2175MGS-like

Sequence similarities

In the 2nd section; belongs to the CarB family.
In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
In the N-terminal section; belongs to the CarA family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,016
  • Mass (Da)
    333,210
  • Last updated
    2012-01-25 v1
  • Checksum
    4620F7501D4BD25A
MMSPRIATKRLQANCRARRTDQQPSDQQPIGVQTSAIDIRIIYVYIMRPRASSSNPQLAPGCTLGRILFLLCINDVYGAISHDERPVFSSSVVYGVARYKTQLRRAQHQQQQTEVSGTTLKGCGRDFEENSCGSVITLGMTVPCHHCTDMLRFMDSPVTVVKGAAIGEGIRSSVGAGSGKYGSESLPKRGNPHRSRSINTSESTPSISRYEQKNYTVTGLWVTWKIQKSNDDQRINGSRGRIPRNTRPLNQPIKETNPDLKATRKRPNNNRTITHKTVELNTPNEENQTKILRPATRCCFRSFISSDRSGGFHPLNPALTMSPRLVKKRLQFNCQAQRTDQQSISAPELPIFHDTARQIHILQTHASFDCIQVDGIGQSSLQLNSNALYGQILIHKESGKITPSNRRDRGNETNEKTRVITPDATQSEVTQKASAGDQAFAQEREETAADETRLLSKLSPERLVGDVPLHGEHTSLFGYRDRHGSMASVFNTDASLPRNRDLFETLIMKEKSRMDLVLPYYNHSKGCDIRKCLPPPNLTHWIITFQLWSTFDFSCFAVKKLLLLFRNRNFRKSMNQCDVKQAEERSFGDSRPLGRLELHDGTVYDGFLYGSCGEAAGEVVFQTGMVGYIESLTDPSYHSQLLVLTYPSIGNYGVPSSQEADEFGLPKWFESNTIYARALIVSELCCDYSHFAAKRSLHEWLAENRVTCLSNIDTRELTLKLRQHGTVLGRIYPLPRGEPVPDWFDPASHNLVSHVSCRQEKIFNANGDVHVAVVDCGVKFNQIRCFCRKGAKVTLLPSSSDLSTRINEFDALFISNGPGDPSHCTHLVDQIRQWMKSNKPLFGICLGHQLVARAVGLETYKMKYGNRGHNQPCIHLETKRCFITSQNHGYSVDVSNLPEGWYELFRNVNDHSNEGLAHRQKPWMTVQFHPEHMAGPQDLEFLFDVFLDQVRSPSDMTLSERLTKTITYDQLRFEQLLAVRPNRPQKILLLGSGGLSIGQAGEFDYSGSQALKALREEGVQTLLINPNVATVQTTSGMADKIFLLPVTPDCVARIIEAERPDGILIGFGGQTGLTCGLALAYPDLNNKTDETLTAPDDNDAPPLSILEQYDCRILGTPAATIEITENRQMFADAMHSIGEKVAPAAAATTVPATVDVANRLGFPVLIRAAFALGGMGSGFAENVEELEQLATRALSQTPQIFIDKSLKGWKEVEYEVVRDAYNNCITVCNMENIDPVGIHTGESIVVAPSQTLSNVEYNMLRSVAIKVACHLHIVGECNIQFALDPNSLTYYIIEVNARLSRSSALASKATGYPLAYIAAKLCLGRSLPELSNVVTGGRTTACFEPSLDYCVVKVPRWDLSKFTRVSRNIGSSMKSVGEVMAISRCFEEAIQKALRMSKPSVLGFTSGDHQADADILADPTDQRIFVLAAALKDGWSVDKIHTLTQIDKWFLYRFAAIAECEKELKTLRDGVLTKIVRLFEDPVTQSVSSSVLPSLHTLIRAKRLGFSDQQIGEALHSSALSVRETREKIYLGPLVRRVDTVAGEWPATTNYLYLSYADIPLAGVLQLGHSNELDRFPNKLQCRLNPSGKHDVSFEPQTQIMVLGSGVYRIGSSVEFDWCAVGCVRELRRLGWSSIMLNCNPETVSTDFDMCDRLYFDELSLERVLDIYKLESAVGVIVSMGGQTPNNIAMPMHRLGVPILGTSAESIDSAENRFKFSRLLDCMGISQPRWRELTDVESAKSFCQQVGYPVLVRPSYVLSGAAMNVAYDPQDLATYLSAAQAISPEHPVVISQFILDAKEIDVDAIAQAGRVVAIAVSEHVENAGVHSGDATLVTPPQDLNAETLDRIKQIVHSLADELQVSGPFNLQVIAKDNRLQIIEANLRVSRSFPFVSKTLKYDFVAAATRCILGSARDSICPPVTGSRTEAAYRHSSSRGFLEPTVDVLNGVPGYVGVKVPVFSFSRLLGADVLLGVEMVSTGEVACFGRDRYEAYLLAQEAALFNTNGRLPRPKESIFLSIGSYRHKKELLTSVSQLSRLGYKLYGSTGTADYYQTQGVPVIPVEWPYEDSDVAKQMYVHFGGAQNSDTDVRDRTVQEYLAEKQFGLIVSLTMRKTGYRRPSAFVTRGYMTRRLAVETNVPLITDVKLFKLLAEALYRHYRGRTLPGKSKDSLLPLRRPDQPGVECRLLPLHCISSSQILYLPGLIDIHVHTRDPGHEYKEDWCTATVAALAGGIVAVLAMPNTNPAVVDEASLQFAMERAASRAYCDYGLFVGATADNAGSVGQLGGHVVGLKMYLNETFSTLSLSGKLNIWKKHFETWPISKPICCHAEGETMAAVLLLAELTGRSVHICHVARKAEIELIRDAKARGLKVTCEVSPHHLFLTEDDLPDCGGWREVRPRLGTREDVQALWANLDSIDCFATDHAPHLASEKATSNAPPGFPGLESMLPLFLTAMCEGRLTLTDLIERLHVNPRRIFNLASDTNLLNAGDTLDRCMFDDTWVEVDMGAEWSLPGSYRVNSPYAEPPVTAPTLYTRAGWSPFAGRRVRGRVRRVVLRGELAFVDGRLLVKPGFGINLASQMTTVIASKAVLQELPRVEVAEHAMISSPVSPVPRTRFESYSERVQDDSVCIGGPSALVDVRSFGPSVPPTSGAPPSVNVSSWIEGISGHHLLSCEGFPKNALHRLFNLAHSFRQAVLKNKPLDDICRGKVMACLFFEPSTRTANSFSVAMQRLGGSVIHFNESVSSLSKGETLSDTLRILASYCDCLVIRHPGKGEVQLAANSVLNRPIINAGDGVGEHPTQAMLDVFTIREEIGTVNGLTVTMVGDLANGRTVHSLARLLCLYNVRLRYVTHCEQLRMPEEVKQYVAARGIPQEEMSSLEEALPDTDVLYMTRVQAERIQSTDSMAVGQFVVTPELMTLAKKSGMIVMHPLPRVGEISPSFDSDPRAAYFRQAEYGITGLGENSSAGQTVFWHAEYVPTSAAFEALGQPSSIPTLVLPVGGMAAWYRKGVTAERLYGTT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias192-209Polar residues
Compositional bias239-257Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DF143923
EMBL· GenBank· DDBJ
GAA54778.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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