F6QZ15 · MICA2_XENTR
- Protein[F-actin]-monooxygenase mical2
- Genemical2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1126 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity).
Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence in the nucleus and promote srf:mkl1/mrtf-a-dependent gene transcription (By similarity).
Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrtf-a presence in the nucleus and promote srf:mkl1/mrtf-a-dependent gene transcription (By similarity).
Catalytic activity
- L-methionyl-[F-actin] + NADPH + O2 + H+ = L-methionyl-(R)-S-oxide-[F-actin] + NADP+ + H2O
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 97 | FAD (UniProtKB | ChEBI) | |||
Binding site | 116-118 | FAD (UniProtKB | ChEBI) | |||
Binding site | 123-125 | FAD (UniProtKB | ChEBI) | |||
Binding site | 183 | FAD (UniProtKB | ChEBI) | |||
Binding site | 299 | FAD (UniProtKB | ChEBI) | |||
Binding site | 399 | FAD (UniProtKB | ChEBI) | |||
Binding site | 1003 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 1006 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 1024 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 1027 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 1030 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1033 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1053 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 1056 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | actin binding | |
Molecular Function | F-actin monooxygenase activity | |
Molecular Function | FAD binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | |
Biological Process | actin filament depolymerization | |
Biological Process | cytoskeleton organization | |
Biological Process | heart development | |
Biological Process | heart looping | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | sulfur oxidation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name[F-actin]-monooxygenase mical2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionF6QZ15
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000416303 | 1-1126 | [F-actin]-monooxygenase mical2 | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, motif, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 2-494 | Monooxygenase domain | |||
Domain | 516-619 | Calponin-homology (CH) | |||
Motif | 659-680 | Nuclear localization signal | |||
Region | 748-830 | Disordered | |||
Compositional bias | 754-773 | Pro residues | |||
Compositional bias | 774-790 | Polar residues | |||
Compositional bias | 806-821 | Basic and acidic residues | |||
Region | 892-935 | Disordered | |||
Compositional bias | 907-921 | Pro residues | |||
Domain | 1001-1063 | LIM zinc-binding | |||
Sequence similarities
Belongs to the Mical family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,126
- Mass (Da)125,940
- Last updated2011-07-27 v1
- MD5 Checksum952115274865629DE6AEC21FAE79F29A
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8J1JEG3 | A0A8J1JEG3_XENTR | mical2 | 873 | ||
A0A8J1JEG5 | A0A8J1JEG5_XENTR | mical2 | 1180 | ||
A0A8J1JHY0 | A0A8J1JHY0_XENTR | mical2 | 1202 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 754-773 | Pro residues | |||
Compositional bias | 774-790 | Polar residues | |||
Compositional bias | 806-821 | Basic and acidic residues | |||
Compositional bias | 907-921 | Pro residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAMC01118102 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118103 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118104 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118105 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118106 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118107 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118108 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118109 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118110 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118111 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118112 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118113 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118114 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118115 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118116 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118117 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118118 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118119 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118120 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118121 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118122 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118123 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118124 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118125 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118126 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01118127 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |