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E6R1Q0 · E6R1Q0_CRYGW

Function

function

Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 1/3.

GO annotations

AspectTerm
Cellular Componentmitochondrial outer membrane
Molecular FunctionFAD binding
Molecular Functionkynurenine 3-monooxygenase activity
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processkynurenine metabolic process
Biological Processquinolinate biosynthetic process
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynurenine 3-monooxygenase
  • EC number
  • Alternative names
    • Biosynthesis of nicotinic acid protein 4
    • Kynurenine 3-hydroxylase

Gene names

    • Name
      BNA4
    • Ordered locus names
      CGB_C6220W

Organism names

Accessions

  • Primary accession
    E6R1Q0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane478-499Helical

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain8-353FAD-binding
Region153-172Disordered

Sequence similarities

Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    56,752
  • Last updated
    2011-03-08 v1
  • MD5 Checksum
    ABC7F880313EA36AA46F156D54AD754B
MPQSRARKALIVGAGPVGALTALSLHRRGWEVEVWESRDDPRCQDAAPSNLRSINLAISSRGLEALRSVDPSIAENFLEEAIPMKGRMIHHTDGRQESQLYDPIGGQSINSISRPILNQRLVQSLPEEIKLRFNTKLNHIDFKNRVAYASHKQGATVMPGEESVEDKKQNTENEDGTAFDLVIGCDGSWSKVRNAMMRVERIDFSQSFIPHAYIELHMPSNPALPGGYAMNKNHLHIWPRHAFMLIGLPNKDGSFTLTLFIPFSSLELITTRESAAAFFKENFPSAVEIVGEKVLLDDFEKNPRGNLVTINCTPSTWSSHAILLGDASHSMVPFYGQGLNCGLEDVRVLNSILERHHISPTTTRALGETDPELELALKAYSDERQGDLKAICELALQNYTEMRSHVLSPLHHLRRQVDKIMTTLFRSTPQATLSLTEPFPTKRVRGWTSLYEMVTFRPDVGYSEALRKERWQKDVVGYTGWIGSVIGISAAGVFAVTMAKKWLERR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000288
EMBL· GenBank· DDBJ
ADV21140.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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