D7EBK7 · MTRA_METEZ
- ProteinTetrahydromethanopterin S-methyltransferase subunit A
- GenemtrA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids241 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Catalytic activity
- 5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na+(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na+(out)
Cofactor
Note: Binds 1 5-hydroxybenzimidazolylcobamide group.
Pathway
One-carbon metabolism; methanogenesis from CO2; methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 85 | 5-hydroxybenzimidazolylcob(I)amide (UniProtKB | ChEBI); cofactor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cobalt ion binding | |
Molecular Function | tetrahydromethanopterin S-methyltransferase activity | |
Biological Process | methanogenesis, from carbon dioxide | |
Biological Process | methylation | |
Biological Process | one-carbon metabolic process | |
Biological Process | sodium ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTetrahydromethanopterin S-methyltransferase subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanosarcinales > Methanosarcinaceae > Methanohalobium
Accessions
- Primary accessionD7EBK7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-220 | Cytoplasmic | |||
Transmembrane | 221-241 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000403065 | 1-241 | Tetrahydromethanopterin S-methyltransferase subunit A | ||
Interaction
Subunit
The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length241
- Mass (Da)26,048
- Last updated2010-08-10 v1
- Checksum54FBC9BA2336657B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002069 EMBL· GenBank· DDBJ | ADI74849.1 EMBL· GenBank· DDBJ | Genomic DNA |