Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

D5U4E5 · D5U4E5_BRAM5

Function

function

Catalyzes the reduction of the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to sn-glycerol 3-phosphate (G3P), the key precursor for phospholipid synthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13NAD+ (UniProtKB | ChEBI)
Binding site12NADPH (UniProtKB | ChEBI)
Binding site31NADPH (UniProtKB | ChEBI)
Binding site48NADPH (UniProtKB | ChEBI)
Binding site105NADPH (UniProtKB | ChEBI)
Binding site105sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site105substrate
Binding site134sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site136sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site138NAD+ (UniProtKB | ChEBI)
Binding site138NADPH (UniProtKB | ChEBI)
Active site189Proton acceptor
Binding site189sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site242sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site252sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site253NAD+ (UniProtKB | ChEBI)
Binding site253NADPH (UniProtKB | ChEBI)
Binding site253sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site253-254substrate
Binding site254sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site278NADPH (UniProtKB | ChEBI)
Binding site280NADPH (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycerol-3-phosphate dehydrogenase (NADP+) activity
Molecular Functionglycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Molecular FunctionNAD binding
Biological Processcarbohydrate metabolic process
Biological Processglycerol-3-phosphate biosynthetic process
Biological Processglycerol-3-phosphate catabolic process
Biological Processglycerophospholipid metabolic process
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol-3-phosphate dehydrogenase [NAD(P)+]
  • EC number
  • Alternative names
    • NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase
    • NAD(P)H-dependent dihydroxyacetone-phosphate reductase

Gene names

    • Name
      gpsA
    • Ordered locus names
      Bmur_0080

Organism names

Accessions

  • Primary accession
    D5U4E5

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-153Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Domain178-319Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    35,914
  • Last updated
    2010-07-13 v1
  • MD5 Checksum
    E10906539C0E1A8014A8E1356071D9A3
MANVGIIGAGGWGLALANIFSEKHNIKVWVHSEESYKLLSTTHRNDNYLENIELNKKINFTMDMGEAVNNNEIIIIVTPSFAFAEACTNIKPYISSDQILVSATKGLDRKTGKTMSEVARSIISGDLSILTLSGPSHAEEAAKGVPTAVVVGGEKGVSEYVRDTLTVPPKFRIYNSTDQKGVEIGGALKNIIAIAGGIVDGLNLGDNTKAALITRGLHEIVRFALSKGARIDTMYGLSGIGDLIVTCSSALSRNNRLGRELAKGKKYEDVISENHGQVAEGVYAATAAYEYAKKNNIYMPITEAIYNILFNNADIQTTLTELMSKDAKSEGFF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001959
EMBL· GenBank· DDBJ
ADG70190.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help