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D5DQW6 · SP2G_PRIM1

Function

function

Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR (By similarity).

Features

Showing features for active site.

130720406080100120140160180200220240260280300
TypeIDPosition(s)Description
Active site183

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processasexual sporulation
Biological Processproteolysis
Biological Processsporulation resulting in formation of a cellular spore

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Sporulation sigma-E factor-processing peptidase
  • EC number
  • Alternative names
    • Membrane-associated aspartic protease
    • Stage II sporulation protein GA

Gene names

    • Name
      spoIIGA
    • Ordered locus names
      BMQ_4271

Organism names

Accessions

  • Primary accession
    D5DQW6
  • Secondary accessions
    • O52061

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Localized to the sporulation septum. Early in sporulating cells localized in an annulus at the septal periphery and later localized uniformly throughout the septa.

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-27Helical
Transmembrane36-56Helical
Transmembrane57-77Helical
Transmembrane89-109Helical
Transmembrane127-147Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004290231-307Sporulation sigma-E factor-processing peptidase

Interaction

Subunit

Self-associates. Interacts with SigE. Interacts with SpoIIR (By similarity).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase U4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    307
  • Mass (Da)
    35,146
  • Last updated
    2014-05-14 v2
  • MD5 Checksum
    34D22672D36519368463C457B94C99BD
MPIYLDLIWMLNFGLDTILLMLCAVVLKRNYKWWRLLLGGFIGSLIVLLMFTPFSHLMVHPAIKILFSFFMVLMTFGYKRLRFFFENLLTFYFATFVVGGGLMGVHFLFQDQFLVLNQMVDTKSPQFGDPISWIFVLIGFPLLSYFSKTRVDDLRIKNITFDQLVDVEIILNEQTLSMKGLIDSGNQLVDPLTKTPVMIVTADSLKEILPEGLMELSKNVQSFSHSEDIDQEWYSKVRFVPYRSVGQANQLLLALKPDMVRLVHQSNTIEVTKVLVGISHTTLSVEKQYECIVHPKLIVIGEVSSAS

Sequence caution

The sequence ADE71281.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict25in Ref. 1; AAB94055

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF017181
EMBL· GenBank· DDBJ
AAB94055.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001983
EMBL· GenBank· DDBJ
ADE71281.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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