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D0VEG3 · D0VEG3_CAPHI

  • Protein
    NADH-ubiquinone oxidoreductase chain 4
  • Gene
    ND4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      ND4
    • ORF names
      KEF96_p04

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 1237
    • 39648
    • V07-146
    • G682
    • 03_Ch37
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Capra

Accessions

  • Primary accession
    D0VEG3

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-42Helical
Transmembrane94-110Helical
Transmembrane116-133Helical
Transmembrane145-167Helical
Transmembrane193-216Helical
Transmembrane223-244Helical
Transmembrane256-277Helical
Transmembrane284-303Helical
Transmembrane309-330Helical
Transmembrane351-369Helical
Transmembrane389-412Helical

Keywords

Expression

Gene expression databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-109NADH:ubiquinone oxidoreductase chain 4 N-terminal
Domain112-402NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    52,026
  • Last updated
    2009-12-15 v1
  • MD5 Checksum
    C692FE533CFDB72356D3B91279F7A8A8
MLKYIIPTMMLMPLTWLSKNNMIWINSTLHSLLISFTSLLLMNQFGDNSLNFSLTFFSDSLSTPLLILTMWLLPLMLMASQHHLLKESPTRKKLFISMLVLLQLFLIMTFTATELIFFYIMFEATLVPTLIIITRWGNQTERLNAGLYFLFYTLTGSLPLLVALIHIQNTVGSLNFLILQYWAQPVPNSWSNVFLWLACMMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLGGYGMMRITLLLNPITDYMAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMAAWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGLNMVITALYSLYMLITTQRGKHTHHINNILPSFTRENALMSLHMLPLLLLSLNPKIILGPLY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU068049
EMBL· GenBank· DDBJ
ACY01507.1
EMBL· GenBank· DDBJ
Genomic DNA
GU295658
EMBL· GenBank· DDBJ
ADB07179.1
EMBL· GenBank· DDBJ
Genomic DNA
KF952601
EMBL· GenBank· DDBJ
AHJ40631.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ192213
EMBL· GenBank· DDBJ
AHW99531.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ940969
EMBL· GenBank· DDBJ
AIG24374.1
EMBL· GenBank· DDBJ
Genomic DNA
KM360063
EMBL· GenBank· DDBJ
AIN79124.1
EMBL· GenBank· DDBJ
Genomic DNA
KM244714
EMBL· GenBank· DDBJ
AIT59322.1
EMBL· GenBank· DDBJ
Genomic DNA
KM670319
EMBL· GenBank· DDBJ
AIX88142.1
EMBL· GenBank· DDBJ
Genomic DNA
KP231536
EMBL· GenBank· DDBJ
AJF41814.1
EMBL· GenBank· DDBJ
Genomic DNA
KP677510
EMBL· GenBank· DDBJ
AJP09224.1
EMBL· GenBank· DDBJ
Genomic DNA
KR059148
EMBL· GenBank· DDBJ
AKS27248.1
EMBL· GenBank· DDBJ
Genomic DNA
KR349363
EMBL· GenBank· DDBJ
AMO01541.1
EMBL· GenBank· DDBJ
Genomic DNA
KY564246
EMBL· GenBank· DDBJ
AQX43742.1
EMBL· GenBank· DDBJ
Genomic DNA
AB735754
EMBL· GenBank· DDBJ
BAN58833.1
EMBL· GenBank· DDBJ
Genomic DNA
MG837555
EMBL· GenBank· DDBJ
QAT80122.1
EMBL· GenBank· DDBJ
Genomic DNA
MT396986
EMBL· GenBank· DDBJ
QOY44842.1
EMBL· GenBank· DDBJ
Genomic DNA
MT134111
EMBL· GenBank· DDBJ
QPZ51708.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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