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C4K4P2 · CLPP_HAMD5

Function

function

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.

Catalytic activity

  • Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
    EC:3.4.21.92 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

121520406080100120140160180200
TypeIDPosition(s)Description
Active site111Nucleophile
Active site136

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentendopeptidase Clp complex
Molecular FunctionATP-dependent peptidase activity
Molecular FunctionATPase binding
Molecular Functionserine-type endopeptidase activity
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent Clp protease proteolytic subunit
  • EC number
  • Alternative names
    • Endopeptidase Clp

Gene names

    • Name
      clpP
    • Ordered locus names
      HDEF_0809

Organism names

Accessions

  • Primary accession
    C4K4P2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002061561-215ATP-dependent Clp protease proteolytic subunit

Interaction

Subunit

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase S14 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    24,259
  • Last updated
    2009-07-07 v1
  • MD5 Checksum
    56D459C100C7E80D86F35A64E4E905E9
MSSFDEQNTRLPSMTLVPMVVEQTSRGERAYDIYSRMLKERVIFLTGQVEEHMANLIVAQMLFLEAENPEKDIYLYINSPGGVITAGMSIYDTMQFITPDVSTICIGQACSMGAFLLAAGAKSKRYCLPNARVMIHQPLGGFQGQASDIEIHAKEILKVKKRMNDLMAIHTKKTLKIIEKDTERDHFLSAEEAKKYGLVDCVLTERKDVKNFSKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001277
EMBL· GenBank· DDBJ
ACQ67535.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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