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C4K3X3 · SPEE_HAMD5

Function

function

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

Catalytic activity

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

Features

Showing features for binding site, active site.

129020406080100120140160180200220240260280
Type
IDPosition(s)Description
Binding site33S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site64spermidine (UniProtKB | ChEBI)
Binding site88spermidine (UniProtKB | ChEBI)
Binding site108S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site140-141S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Active site158Proton acceptor
Binding site158-161spermidine (UniProtKB | ChEBI)
Binding site165S-methyl-5'-thioadenosine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionspermidine synthase activity
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyamine aminopropyltransferase
  • Alternative names
    • Putrescine aminopropyltransferase
      (PAPT
      )
    • Spermidine synthase
      (SPDS
      ; SPDSY
      ) (EC:2.5.1.16
      ) . EC:2.5.1.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      speE
    • Ordered locus names
      HDEF_0512

Organism names

Accessions

  • Primary accession
    C4K3X3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002040751-290Polyamine aminopropyltransferase

Interaction

Subunit

Homodimer or homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-238PABS

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    290
  • Mass (Da)
    33,249
  • Last updated
    2009-07-07 v1
  • MD5 Checksum
    BFBCD8A23916E5B55E1B65DD8FED0D01
MSQKQLWYEKLHSSFGQYFSIKEVLYRDKTDHQDLIIFDTEEFGRVMALNHVVQTTERDEFIYHEMMTHVPLLAHGDAKKVLIIGGGDGGILREVCRHAGVKEIIMVEIDQDVVNLCQEYFPHHHAGAYDDPRFQLKIDDGAHFVEQTNHRFDLIISDSTDPIGPGEHLFKSSFYQACRRILNAGGLFVAQNGVCFLQQTEVINTYQRLMPYFSDVSFYQAAIPTYYGGIMTFAWASENANLRRIGLNDLESRFADSGLKSCRYYNPFVHFASFALPQYLIEALAKKAPK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001277
EMBL· GenBank· DDBJ
ACQ67266.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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