C4K3X3 · SPEE_HAMD5
- ProteinPolyamine aminopropyltransferase
- GenespeE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids290 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Catalytic activity
- S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H+
Pathway
Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 33 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Binding site | 64 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 88 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 108 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Binding site | 140-141 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
Active site | 158 | Proton acceptor | |||
Binding site | 158-161 | spermidine (UniProtKB | ChEBI) | |||
Binding site | 165 | S-methyl-5'-thioadenosine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | spermidine synthase activity | |
Biological Process | spermidine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePolyamine aminopropyltransferase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > aphid secondary symbionts > Candidatus Hamiltonella
Accessions
- Primary accessionC4K3X3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000204075 | 1-290 | Polyamine aminopropyltransferase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length290
- Mass (Da)33,249
- Last updated2009-07-07 v1
- MD5 ChecksumBFBCD8A23916E5B55E1B65DD8FED0D01
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP001277 EMBL· GenBank· DDBJ | ACQ67266.1 EMBL· GenBank· DDBJ | Genomic DNA |