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B8RGQ5 · B8RGQ5_HELPX

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site16-18shikimate (UniProtKB | ChEBI)
Binding site65shikimate (UniProtKB | ChEBI)
Active site69Proton acceptor
Binding site90shikimate (UniProtKB | ChEBI)
Binding site105shikimate (UniProtKB | ChEBI)
Binding site125-129NADP+ (UniProtKB | ChEBI)
Binding site208NADP+ (UniProtKB | ChEBI)
Binding site210shikimate (UniProtKB | ChEBI)
Binding site230NADP+ (UniProtKB | ChEBI)
Binding site237shikimate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • ORF names
      HP01249

Organism names

Accessions

  • Primary accession
    B8RGQ5

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-92Shikimate dehydrogenase substrate binding N-terminal

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    263
  • Mass (Da)
    28,911
  • Last updated
    2009-03-03 v1
  • MD5 Checksum
    BF364CFEE3002EAE0EC2ABACC8EE9C95
MKLKSFGVLGNPIKHSKSPLIHNACFLTFQKELGFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQICDKIKGIALECGAVNTLVLEDDELVGYNTDALGFWLSLGNEGYQSALILGSGGSAKALACELKKQGLQVSVLNRSARGLDFFQRLGCDCFIEPPKSAFDLIINATSASLNNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKGMLIYQAALSFEKFSASQIPYSKAFEVMRSVF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
EU939304
EMBL· GenBank· DDBJ
ACK99715.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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