B8RGQ5 · B8RGQ5_HELPX
- ProteinShikimate dehydrogenase (NADP(+))
- GenearoE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids263 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Catalytic activity
- shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+
Pathway
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 16-18 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 65 | shikimate (UniProtKB | ChEBI) | |||
Active site | 69 | Proton acceptor | |||
Binding site | 90 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 105 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 125-129 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 208 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 210 | shikimate (UniProtKB | ChEBI) | |||
Binding site | 230 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 237 | shikimate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | shikimate 3-dehydrogenase (NADP+) activity | |
Biological Process | amino acid biosynthetic process | |
Biological Process | aromatic amino acid family biosynthetic process | |
Biological Process | chorismate biosynthetic process | |
Biological Process | shikimate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShikimate dehydrogenase (NADP(+))
- EC number
- Short namesSDH
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Helicobacteraceae > Helicobacter
Accessions
- Primary accessionB8RGQ5
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homodimer.
Structure
Sequence
- Sequence statusComplete
- Length263
- Mass (Da)28,911
- Last updated2009-03-03 v1
- MD5 ChecksumBF364CFEE3002EAE0EC2ABACC8EE9C95
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU939304 EMBL· GenBank· DDBJ | ACK99715.1 EMBL· GenBank· DDBJ | Genomic DNA |