B7MI93 · ARGE_ECO45

Function

function

Catalyzes the hydrolysis of the amide bond of N2-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Note: Binds 2 Zn2+ or Co2+ ions per subunit.
glutathione (UniProtKB | Rhea| CHEBI:57925 )

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N2-acetyl-L-ornithine (linear): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site80Zn2+ 1 (UniProtKB | ChEBI)
Active site82
Binding site112Zn2+ 1 (UniProtKB | ChEBI)
Binding site112Zn2+ 2 (UniProtKB | ChEBI)
Active site144
Binding site145Zn2+ 2 (UniProtKB | ChEBI)
Binding site169Zn2+ 1 (UniProtKB | ChEBI)
Binding site355Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionacetylornithine deacetylase activity
Molecular Functionzinc ion binding
Biological Processarginine biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetylornithine deacetylase
  • EC number
  • Short names
    AO
    ; Acetylornithinase
  • Alternative names
    • N-acetylornithinase
      (NAO
      )

Gene names

    • Name
      argE
    • Ordered locus names
      ECS88_4412

Organism names

Accessions

  • Primary accession
    B7MI93

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10001370611-383Acetylornithine deacetylase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M20A family. ArgE subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    383
  • Mass (Da)
    42,266
  • Last updated
    2009-02-10 v1
  • MD5 Checksum
    38E24125F7267E16FEF3F44402F8D42B
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASCGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLAKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYDAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVSERWPGRLTVDELHPPIPGYECPPNHQLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU928161
EMBL· GenBank· DDBJ
CAR05591.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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