B4S5Y9 · GLYA_PROA2

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.
Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site119(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site123-125(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site227Plays an important role in substrate specificity
Binding site370-372(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine biosynthetic process from serine
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • Ordered locus names
      Paes_0584

Organism names

Accessions

  • Primary accession
    B4S5Y9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_10000915681-440Serine hydroxymethyltransferase
Modified residue228N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    440
  • Mass (Da)
    47,415
  • Last updated
    2008-09-23 v1
  • MD5 Checksum
    3238F97FE9D783B96624E2D51EC3DCD4
MSIEILQKQDKEIFDAISNEVLRQTETLELIASENFASKAVMEACGSVMTNKYAEGYPGKRYYGGCEFVDVAEDLARERAKKLFGCQYVNVQPHSGSSANMGVLFSVLKPGDTIMGLDLSHGGHLTHGSSVNFSGQLFDAHSYGVDRETGLIDMDRVEDMALSVRPRLIICGASAYSQGFDFKAFRQIADKVGAFLMADIAHPAGLIAAGLLNDPMPHCHFVTTTTHKTLRGPRGGMIMMGEDFENPMGITIKTKAGRRTKMMSEVIDAEIMPGIQGGPLMHIIAAKAVAFGEALQPEFKEYAVQVRANAAAMAQKFISLDYNIVSGGTKNHLMLIDLRNKNVTGKVAENLLHEAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMTESHAEAIVSLIDRVIGAAGSPDAGTVCGEVRSEIKAMCGTLPLNDFSPTL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP001108
EMBL· GenBank· DDBJ
ACF45640.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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