B4NDL8 · NAAT1_DROWI

Function

function

Unusual broad substrate spectrum amino acid:sodium cotransporter that promotes absorption of the D isomers of essential amino acids. Neutral amino acids are the preferred substrates, especially methionine and phenylalanine (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionamino acid:sodium symporter activity
Molecular FunctionD-amino acid transmembrane transporter activity
Molecular FunctionL-amino acid transmembrane transporter activity
Molecular Functionneutral L-amino acid transmembrane transporter activity
Biological ProcessD-amino acid transport
Biological Processneutral amino acid transport
Biological Processsodium ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium-dependent nutrient amino acid transporter 1

Gene names

    • Name
      NAAT1
    • ORF names
      GK25473

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 14030-0811.24
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    B4NDL8

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-38Cytoplasmic
Transmembrane39-59Helical; Name=1
Transmembrane72-92Helical; Name=2
Transmembrane125-145Helical; Name=3
Transmembrane229-249Helical; Name=4
Transmembrane258-278Helical; Name=5
Transmembrane307-327Helical; Name=6
Transmembrane341-361Helical; Name=7
Transmembrane401-421Helical; Name=8
Transmembrane441-461Helical; Name=9
Transmembrane474-494Helical; Name=10
Transmembrane516-536Helical; Name=11
Transmembrane552-572Helical; Name=12

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00003865891-641Sodium-dependent nutrient amino acid transporter 1
Glycosylation181N-linked (GlcNAc...) asparagine
Glycosylation190N-linked (GlcNAc...) asparagine
Glycosylation198N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias1-24Polar residues
Region1-37Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    641
  • Mass (Da)
    71,796
  • Last updated
    2008-09-23 v1
  • Checksum
    6D8C2C9B7CE2D953
MELKNIEQQPQLQNGNGTATENNEKGEQKPTEGGERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIIGQFTSQGSVKIWSICPSFLGVGYGQAFATVCIISYYSSLLALTLYYLFVSFQSVLPWSYCRDEWTNCVNSRPEDYSSTMLEAARNATSSLLIGNETTSLADNDSVQLQSSSELYFLNVVIKEKLDISDGVGAPDWKLTLALLVSWIVTFLVIMRGVKSSGKAAYFLAIFPYVVLFVLLGRAVTLEGAVDGIIFFLQPQWGELLNPTVWKEAVVQCFFSLAVSCGPIIMFASYNRFDHSIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQVDNIREVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKSWKYWKVALVTSICGFLLGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWIYGLQNFCDDIEFMCNKRVSLYWRVCWSFFTPVMMIIIFIYSMATIEPLKYSDLYFPLAGDIAGWIVFAIGTAQFPLWGIWYISHHRNGNLWQSFVSCLKPNENWGPANPETKQAWLLFKSEKARQRASKTQSSKMGQFWQKVGNFCGSST

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-24Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH964239
EMBL· GenBank· DDBJ
EDW81840.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp