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B4F446 · B4F446_HOMNE

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 6
  • EC number

Gene names

    • Name
      ND6

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • El Sidron 1253
    • Feldhofer 1
    • Feldhofer 2
    • Mezmaiskaya 1
    • Vindija 33.25
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B4F446

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-46Helical
Transmembrane53-75Helical
Transmembrane81-104Helical
Transmembrane111-128Helical
Transmembrane148-168Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-15
ChainPRO_501193518316-174NADH-ubiquinone oxidoreductase chain 6

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Structure

Family & Domains

Sequence similarities

Belongs to the complex I subunit 6 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    174
  • Mass (Da)
    18,608
  • Last updated
    2008-09-23 v1
  • MD5 Checksum
    2768D23C4AAB9E7B2471DB18F02BDE92
MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYLGGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYVVIEIARGN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KC879692
EMBL· GenBank· DDBJ
AGO20291.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ533544
EMBL· GenBank· DDBJ
AHZ61457.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ533545
EMBL· GenBank· DDBJ
AHZ61470.1
EMBL· GenBank· DDBJ
Genomic DNA
KU131206
EMBL· GenBank· DDBJ
AMQ34022.1
EMBL· GenBank· DDBJ
Genomic DNA
KX198082
EMBL· GenBank· DDBJ
ANC95135.1
EMBL· GenBank· DDBJ
Genomic DNA
KX198084
EMBL· GenBank· DDBJ
ANC95161.1
EMBL· GenBank· DDBJ
Genomic DNA
KX198085
EMBL· GenBank· DDBJ
ANC95174.1
EMBL· GenBank· DDBJ
Genomic DNA
KX198086
EMBL· GenBank· DDBJ
ANC95187.1
EMBL· GenBank· DDBJ
Genomic DNA
KX198087
EMBL· GenBank· DDBJ
ANC95200.1
EMBL· GenBank· DDBJ
Genomic DNA
KX198088
EMBL· GenBank· DDBJ
ANC95213.1
EMBL· GenBank· DDBJ
Genomic DNA
KY751400
EMBL· GenBank· DDBJ
ASK06276.1
EMBL· GenBank· DDBJ
Genomic DNA
MG025536
EMBL· GenBank· DDBJ
AUD37482.1
EMBL· GenBank· DDBJ
Genomic DNA
MG025537
EMBL· GenBank· DDBJ
AUD37495.1
EMBL· GenBank· DDBJ
Genomic DNA
MG025538
EMBL· GenBank· DDBJ
AUD37508.1
EMBL· GenBank· DDBJ
Genomic DNA
MG025539
EMBL· GenBank· DDBJ
AUD37521.1
EMBL· GenBank· DDBJ
Genomic DNA
MG025540
EMBL· GenBank· DDBJ
AUD37534.1
EMBL· GenBank· DDBJ
Genomic DNA
AM948965
EMBL· GenBank· DDBJ
CAQ37657.1
EMBL· GenBank· DDBJ
Genomic DNA
FM865407
EMBL· GenBank· DDBJ
CAR95812.1
EMBL· GenBank· DDBJ
Genomic DNA
FM865408
EMBL· GenBank· DDBJ
CAR95825.1
EMBL· GenBank· DDBJ
Genomic DNA
FM865409
EMBL· GenBank· DDBJ
CAR95838.1
EMBL· GenBank· DDBJ
Genomic DNA
FM865410
EMBL· GenBank· DDBJ
CAR95851.1
EMBL· GenBank· DDBJ
Genomic DNA
FM865411
EMBL· GenBank· DDBJ
CAR95864.1
EMBL· GenBank· DDBJ
Genomic DNA
MK033602
EMBL· GenBank· DDBJ
QAU54317.1
EMBL· GenBank· DDBJ
Genomic DNA
MK123269
EMBL· GenBank· DDBJ
QEE94739.1
EMBL· GenBank· DDBJ
Genomic DNA
MK388903
EMBL· GenBank· DDBJ
QIT06505.1
EMBL· GenBank· DDBJ
Genomic DNA
MT795654
EMBL· GenBank· DDBJ
QOI14018.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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