B3KXR5 · B3KXR5_HUMAN

  • Protein
    Phosphoinositide phospholipase C
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 3 Ca2+ ions per subunit. Two of the Ca2+ ions are bound to the C2 domain.

Features

Showing features for active site, binding site.

155050100150200250300350400450500550
Type
IDPosition(s)Description
Active site105
Binding site106Ca2+ 3 (UniProtKB | ChEBI); catalytic
Binding site135Ca2+ 3 (UniProtKB | ChEBI); catalytic
Binding site137Ca2+ 3 (UniProtKB | ChEBI); catalytic
Active site150
Binding site184Ca2+ 3 (UniProtKB | ChEBI); catalytic
Binding site232substrate
Binding site234substrate
Binding site316substrate
Binding site343substrate
Binding site445Ca2+ 4 (UniProtKB | ChEBI)
Binding site447Ca2+ 4 (UniProtKB | ChEBI)
Binding site471Ca2+ 4 (UniProtKB | ChEBI)
Binding site500Ca2+ 5 (UniProtKB | ChEBI)
Binding site501Ca2+ 5 (UniProtKB | ChEBI)
Binding site502Ca2+ 5 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processintracellular signal transduction
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoinositide phospholipase C
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    B3KXR5

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain286-403PI-PLC Y-box
Domain405-531C2

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    550
  • Mass (Da)
    61,179
  • Last updated
    2008-09-02 v1
  • Checksum
    F456832D957452CA
MLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIEHYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAVMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWRDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK127813
EMBL· GenBank· DDBJ
BAG54577.1
EMBL· GenBank· DDBJ
mRNA

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