B3KXR5 · B3KXR5_HUMAN
- ProteinPhosphoinositide phospholipase C
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids550 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
Cofactor
Note: Binds 3 Ca2+ ions per subunit. Two of the Ca2+ ions are bound to the C2 domain.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 105 | ||||
Binding site | 106 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Binding site | 135 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Binding site | 137 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Active site | 150 | ||||
Binding site | 184 | Ca2+ 3 (UniProtKB | ChEBI); catalytic | |||
Binding site | 232 | substrate | |||
Binding site | 234 | substrate | |||
Binding site | 316 | substrate | |||
Binding site | 343 | substrate | |||
Binding site | 445 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 447 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 471 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 500 | Ca2+ 5 (UniProtKB | ChEBI) | |||
Binding site | 501 | Ca2+ 5 (UniProtKB | ChEBI) | |||
Binding site | 502 | Ca2+ 5 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoinositide phospholipase C
- EC number
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionB3KXR5
Structure
Sequence
- Sequence statusComplete
- Length550
- Mass (Da)61,179
- Last updated2008-09-02 v1
- ChecksumF456832D957452CA
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK127813 EMBL· GenBank· DDBJ | BAG54577.1 EMBL· GenBank· DDBJ | mRNA |