B1IBM3 · MURA1_STRPI
- ProteinUDP-N-acetylglucosamine 1-carboxyvinyltransferase
- GenemurA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids419 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity).
Target for the antibiotic fosfomycin
Target for the antibiotic fosfomycin
Miscellaneous
This strain of S.pneumoniae has no heteroresistance to fosfomycin unlike other strains of this bacterium in which MurA1 is required for heteroresistance along with other as yet unknown factor(s). Heteroresistance is the ability of a clonal population to grow one or several subpopulations at a frequency of 10-7 to 10-3 in the presence of a higher antibiotic concentration than that predicted to be effective by measurement of the minimum inhibitory concentration (MIC).
Catalytic activity
- phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + phosphate
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 22-23 | phosphoenolpyruvate (UniProtKB | ChEBI) | |||
Binding site | 92 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | |||
Active site | 116 | Proton donor | |||
Binding site | 121-125 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | |||
Binding site | 306 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | |||
Binding site | 328 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape | |
Biological Process | UDP-N-acetylgalactosamine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylglucosamine 1-carboxyvinyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionB1IBM3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000436447 | 1-419 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | ||
Modified residue | 116 | 2-(S-cysteinyl)pyruvic acid O-phosphothioketal | |||
Structure
Sequence
- Sequence statusComplete
- Length419
- Mass (Da)45,055
- Last updated2008-04-29 v1
- MD5 Checksum3330F4A0D49714230BB38637B9479058
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000936 EMBL· GenBank· DDBJ | ACA37082.1 EMBL· GenBank· DDBJ | Genomic DNA |