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B1IBM3 · MURA1_STRPI

Function

function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine (By similarity).
Target for the antibiotic fosfomycin

Miscellaneous

This strain of S.pneumoniae has no heteroresistance to fosfomycin unlike other strains of this bacterium in which MurA1 is required for heteroresistance along with other as yet unknown factor(s). Heteroresistance is the ability of a clonal population to grow one or several subpopulations at a frequency of 10-7 to 10-3 in the presence of a higher antibiotic concentration than that predicted to be effective by measurement of the minimum inhibitory concentration (MIC).

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site22-23phosphoenolpyruvate (UniProtKB | ChEBI)
Binding site92UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Active site116Proton donor
Binding site121-125UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site306UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)
Binding site328UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionUDP-N-acetylglucosamine 1-carboxyvinyltransferase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape
Biological ProcessUDP-N-acetylgalactosamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase
  • EC number
  • Alternative names
    • Enoylpyruvate transferase
      (EPT
      )
    • UDP-N-acetylglucosamine enolpyruvyl transferase

Gene names

    • Name
      murA1
    • Synonyms
      murA
    • Ordered locus names
      SPH_1173

Organism names

Accessions

  • Primary accession
    B1IBM3

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00004364471-419UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Modified residue1162-(S-cysteinyl)pyruvic acid O-phosphothioketal

Family & Domains

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    419
  • Mass (Da)
    45,055
  • Last updated
    2008-04-29 v1
  • MD5 Checksum
    3330F4A0D49714230BB38637B9479058
MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGTSVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGYSDIIEKLRNLGADIRLVED

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000936
EMBL· GenBank· DDBJ
ACA37082.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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