A9MK49 · END4_SALAR

Function

function

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.
    EC:3.1.21.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 3 Zn2+ ions.

Features

Showing features for binding site.

128520406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site69Zn2+ 1 (UniProtKB | ChEBI)
Binding site109Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 1 (UniProtKB | ChEBI)
Binding site145Zn2+ 2 (UniProtKB | ChEBI)
Binding site179Zn2+ 2 (UniProtKB | ChEBI)
Binding site182Zn2+ 3 (UniProtKB | ChEBI)
Binding site216Zn2+ 2 (UniProtKB | ChEBI)
Binding site229Zn2+ 3 (UniProtKB | ChEBI)
Binding site231Zn2+ 3 (UniProtKB | ChEBI)
Binding site261Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functiondeoxyribonuclease IV (phage-T4-induced) activity
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functionphosphoric diester hydrolase activity
Molecular Functionzinc ion binding
Biological Processbase-excision repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable endonuclease 4
  • EC number
  • Alternative names
    • Endodeoxyribonuclease IV
    • Endonuclease IV

Gene names

    • Name
      nfo
    • Ordered locus names
      SARI_00686

Organism names

Accessions

  • Primary accession
    A9MK49

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000768071-285Probable endonuclease 4

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the AP endonuclease 2 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    285
  • Mass (Da)
    31,207
  • Last updated
    2008-02-05 v1
  • Checksum
    87DFE8E949F18696
MKYIGAHVSAAGGLANAPARAAEIGATAFALFTKNQRQWRAAPLIPQVIDDFKIACEKYHFSAAQILPHDSYLINLGHPVSEALEKSRDAFLDEMQRCEQLGLTLLNFHPGSHLMQIAQEDCLARIAESINIALAQTEGVTAVIENTAGQGSNLGFEFEQLAAIIDGVEDKSRVGVCIDTCHAFAAGYDLRTPEACEKTFAEFGQIVGFQYLRGMHLNDAKSAFGSRVDRHHSLGEGNIGHDAFRWIMQDARFDGIPLVLETINPDIWAEEIAWLKAQQSEKAVA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000880
EMBL· GenBank· DDBJ
ABX20609.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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