A9IVX0 · LIPB_BART1

Function

function

Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

Miscellaneous

In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site93-100substrate
Site170Lowers pKa of active site Cys
Binding site173-175substrate
Binding site186-188substrate
Active site204Acyl-thioester intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionlipoyl(octanoyl) transferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Octanoyltransferase
  • EC number
  • Alternative names
    • Lipoate-protein ligase B
    • Lipoyl/octanoyl transferase
    • Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase

Gene names

    • Name
      lipB
    • Ordered locus names
      BT_1472

Organism names

Accessions

  • Primary accession
    A9IVX0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000739951-245Octanoyltransferase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain54-242BPL/LPL catalytic

Sequence similarities

Belongs to the LipB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    27,895
  • Last updated
    2008-02-05 v1
  • MD5 Checksum
    723D0A0E86F79CA79E5DD1231BC8B4FF
MTFELKHRDRSHLSHHFNAILGNPPVEWKISDHLVEYPEALRYMQERVEKILAKTAHEQVWLLEHPSLYTAGTSADKKDLLAPHLFPVYEAGRGGEFTYHGPGQRIAYIMLDLKRRKQDIRAFISALEEWIIQMLASFNIKGERREDRVGVWVKQSHCPSKKNDLSSEDKIAAIGIRVRKWISFHGVSINVNPNLAHYSGIVPCGITNHGVTSFLNLGCPVTMHDIDIALKHAFEKIFGPTIDVS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM260525
EMBL· GenBank· DDBJ
CAK01821.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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