A9IVC8 · CTAA_BART1

Function

function

Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site271Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue
Binding site332Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
Biological Processheme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme A synthase
  • EC number
  • Short names
    HAS
  • Alternative names
    • Cytochrome aa3-controlling protein

Gene names

    • Name
      ctaA
    • Synonyms
      cox15
    • Ordered locus names
      BT_1320

Organism names

Accessions

  • Primary accession
    A9IVC8

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane22-42Helical
Transmembrane107-127Helical
Transmembrane133-153Helical
Transmembrane172-192Helical
Transmembrane208-228Helical
Transmembrane269-289Helical
Transmembrane302-322Helical
Transmembrane324-344Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003490151-358Heme A synthase

Interaction

Subunit

Interacts with CtaB.

Structure

Family & Domains

Sequence similarities

Belongs to the COX15/CtaA family. Type 2 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    358
  • Mass (Da)
    40,910
  • Last updated
    2008-02-05 v1
  • MD5 Checksum
    E6AA0893FBCE46B90D51C5071DAD8F9C
MAVKRLNDNLLTPVQKRNRKQIQVWLYSILLLCLAIVLVGGATRLTGSGLSITEWKPIHGVIPPIGVEQWQEEFLKYQQITQYKLLNRDMTLSAFKVIFWWEWAHRVLGRLVGLVALLGLIWFWATKRIEKNILFPLIVVPILIAFQGFIGWWMVASGIGQSNLTSVSQYRLAFHLITACLVIIFVTYLSRGLTEYSEKPANQKVQCFAAWLVILVLIEIYLGALVAGLHAGKVYNTWPLMDGQIIPDGLLQHHPYWLNLFENPLTVQFIHRFFAYFLFIVSALHAFYVQKNAPHSTHSRRAFLIFFIIIIQAILGILTLLHEVPISLGLIHQSMALVVLCFAVAHWRATKGAYRAVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AM260525
EMBL· GenBank· DDBJ
CAK01684.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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