A9A432 · NNRE_NITMS
- ProteinNAD(P)H-hydrate epimerase
- GenennrE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids215 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Catalytic activity
- (6R)-NADHX = (6S)-NADHX
Cofactor
Note: Binds 1 potassium ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 57-61 | (6S)-NADPHX (UniProtKB | ChEBI) | |||
Binding site | 58 | K+ (UniProtKB | ChEBI) | |||
Binding site | 124 | K+ (UniProtKB | ChEBI) | |||
Binding site | 128-134 | (6S)-NADPHX (UniProtKB | ChEBI) | |||
Binding site | 139 | (6S)-NADPHX (UniProtKB | ChEBI) | |||
Binding site | 157 | (6S)-NADPHX (UniProtKB | ChEBI) | |||
Binding site | 160 | K+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | NADHX epimerase activity | |
Molecular Function | NADPHX epimerase activity | |
Molecular Function | nucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(P)H-hydrate epimerase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Nitrososphaerota > Nitrososphaeria > Nitrosopumilales > Nitrosopumilaceae > Nitrosopumilus
Accessions
- Primary accessionA9A432
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000416382 | 1-215 | NAD(P)H-hydrate epimerase | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length215
- Mass (Da)23,584
- Last updated2008-01-15 v1
- MD5 Checksum06680669A2CE5917E5F3DFED6B6EC209
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000866 EMBL· GenBank· DDBJ | ABX12216.1 EMBL· GenBank· DDBJ | Genomic DNA |