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A9A432 · NNRE_NITMS

Function

function

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Catalytic activity

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site57-61(6S)-NADPHX (UniProtKB | ChEBI)
Binding site58K+ (UniProtKB | ChEBI)
Binding site124K+ (UniProtKB | ChEBI)
Binding site128-134(6S)-NADPHX (UniProtKB | ChEBI)
Binding site139(6S)-NADPHX (UniProtKB | ChEBI)
Binding site157(6S)-NADPHX (UniProtKB | ChEBI)
Binding site160K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Molecular Functionnucleotide binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD(P)H-hydrate epimerase
  • EC number
  • Alternative names
    • NAD(P)HX epimerase

Gene names

    • Name
      nnrE
    • Ordered locus names
      Nmar_0320

Organism names

Accessions

  • Primary accession
    A9A432

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004163821-215NAD(P)H-hydrate epimerase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-212YjeF N-terminal

Sequence similarities

Belongs to the NnrE/AIBP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    215
  • Mass (Da)
    23,584
  • Last updated
    2008-01-15 v1
  • MD5 Checksum
    06680669A2CE5917E5F3DFED6B6EC209
MEITVDQMYNIENKGHDMGFLKKFMMENAGAAAVKRLVEKLGNVDSKNILIFVGMGNNGGDGLVMARHLAGYNAKVTVMLLGNPENIKTEESNWNWSILEKMPSVKLMTGGTTNFDFKPDVIVDGILGTGISGEIREPYASAINYINQTDCYKFAVDVPSGLDPQTGETANIFTKCDMTVTFHKMKQGIPKRKDLTGELFAEKIGIPPEAEEGIL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000866
EMBL· GenBank· DDBJ
ABX12216.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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