Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A9A233 · AROE_NITMS

Function

function

Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.

Features

Showing features for binding site, active site.

127320406080100120140160180200220240260
Type
IDPosition(s)Description
Binding site15-17shikimate (UniProtKB | ChEBI)
Binding site62shikimate (UniProtKB | ChEBI)
Active site66Proton acceptor
Binding site78NADP+ (UniProtKB | ChEBI)
Binding site87shikimate (UniProtKB | ChEBI)
Binding site102shikimate (UniProtKB | ChEBI)
Binding site126-130NADP+ (UniProtKB | ChEBI)
Binding site150-155NADP+ (UniProtKB | ChEBI)
Binding site217NADP+ (UniProtKB | ChEBI)
Binding site219shikimate (UniProtKB | ChEBI)
Binding site240NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionNADP binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process
Biological Processshikimate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Shikimate dehydrogenase (NADP(+))
  • EC number
  • Short names
    SDH

Gene names

    • Name
      aroE
    • Ordered locus names
      Nmar_0550

Organism names

Accessions

  • Primary accession
    A9A233

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10002042691-273Shikimate dehydrogenase (NADP+)

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the shikimate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    273
  • Mass (Da)
    29,824
  • Last updated
    2008-01-15 v1
  • MD5 Checksum
    BC92CFA9931D6497104939C76818A85E
MGKTFAVIGDPIDHSLSPNIHSAAFRELNLDCSYIAYRIPKDELGEGIEGLKKIQIAGFNVTIPHKIEMMKYLDKIDESCSLIGAVNTVVSNDGVLKGYNTDMDGFLEPLKKRNIEIENSNVLLLGAGGAARAIVAGFAKEKAKSITIANRTIEKANNLVEFAKKISLDANAITIDQVGESAKDYNIIVNATSIGLQNESSPISFEGVNEKTVVYDIVYLPMNTDFLKKAKEKNATIIFGYEMLLGQAVRAFEIWHGMEAPYNAMKKALLGGF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000866
EMBL· GenBank· DDBJ
ABX12446.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help