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A5F120 · NHAD_VIBC3

Function

function

Na+/H+ antiporter that extrudes sodium in exchange for external protons. Can also transport lithium.

pH Dependence

Optimum pH is 8.0. Totally inactive at pH 9.0.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionantiporter activity
Biological Processsodium ion transport

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Na(+)/H(+) antiporter NhaD
  • Alternative names
    • Sodium/proton antiporter NhaD

Gene names

    • Name
      nhaD
    • Ordered locus names
      VC0395_0225, VC395_A1039

Organism names

Accessions

  • Primary accession
    A5F120
  • Secondary accessions
    • Q7DCN4
    • Q9EYG4
    • Q9KKT5

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-33Periplasmic
Transmembrane34-51Helical
Topological domain52-60Cytoplasmic
Transmembrane61-78Helical
Topological domain79-94Periplasmic
Transmembrane95-112Helical
Topological domain113-132Cytoplasmic
Transmembrane133-150Helical
Topological domain151-154Periplasmic
Transmembrane155-171Helical
Topological domain172-181Cytoplasmic
Transmembrane182-206Helical
Topological domain207-220Periplasmic
Transmembrane221-238Helical
Topological domain239-258Cytoplasmic
Transmembrane259-277Helical
Topological domain278-281Periplasmic
Transmembrane282-299Helical
Topological domain300-344Cytoplasmic
Transmembrane345-362Helical
Topological domain363-378Periplasmic
Transmembrane379-403Helical
Topological domain404-413Cytoplasmic
Transmembrane414-438Helical
Topological domain439-454Periplasmic
Transmembrane455-472Helical
Topological domain473-477Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis93Shifts the pH optimum to more acidic pH.
Mutagenesis100No change in activity. Shifts the pH optimum to more alkaline pH.
Mutagenesis150Lack of activity.
Mutagenesis154Lack of activity.
Mutagenesis155Lack of activity.
Mutagenesis157Decrease in activity.
Mutagenesis189Lack of activity.
Mutagenesis199Lack of activity.
Mutagenesis201Lack of activity.
Mutagenesis202Lack of activity.
Mutagenesis210Shifts the pH optimum to more acidic pH.
Mutagenesis251No change in activity. Shifts the pH optimum to more alkaline pH.
Mutagenesis274No change in activity.
Mutagenesis278No change in activity.
Mutagenesis342No change in activity. Shifts the pH optimum to more alkaline pH.
Mutagenesis344Lack of activity.
Mutagenesis344Decrease in activity.
Mutagenesis345Lack of activity.
Mutagenesis389Lack of activity.
Mutagenesis390No change in activity.
Mutagenesis393No change in activity. Shifts the pH optimum to more alkaline pH.
Mutagenesis393Lack of activity.
Mutagenesis394Lack of activity.
Mutagenesis425Lack of activity.
Mutagenesis428Decrease in activity.
Mutagenesis431Lack of activity.
Mutagenesis450No change in activity.
Mutagenesis468No change in activity.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004236611-477Na+/H+ antiporter NhaD

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    477
  • Mass (Da)
    52,378
  • Last updated
    2007-06-12 v1
  • MD5 Checksum
    39417C489F1E465E738DC93A1073DEDD
MTGRIALLSLTLFSPLSLASTPDGQALDFTHSTIGYAALLIFAIAYTLVMLEEYLQLRKSKPVLLAAGLIWAMIGYVYQQTGSTEVARQALEHNLLEYAELLLFLLVAMTYISAMEERRLFDALKAWMINRGFNFHTLFWITGWLAFFISPIADNLTTALLMCAVVMKVGGENPKFVSLACINIVIAANAGGAFSPFGDITTLMVWQAGHVSFLEFMDLFLPSLANYLVPALVMSLFVPHQTPSSIQEVVELKRGAKRIVVLFLFTILSAIGFHAFFHFPPVIGMMMGLAYLQFFGYFLRKTLARSLAKKTAIAMAKNDEAALKRIGSVVPFDVFRSISHAEWDTLLFFYGVVMCVGGLSLLGYLGLVSEILYTEWNPIWANVLVGLLSSVVDNIPVMFAVLSMQPEMSLGNWLLVTLTAGVGGSLLSIGSAAGVALMGAAHGKYTFLSHLKWTPVILLGYVVSIVLHLLLNHQSFT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF331042
EMBL· GenBank· DDBJ
AAG48354.2
EMBL· GenBank· DDBJ
Genomic DNA
CP000626
EMBL· GenBank· DDBJ
ABQ19159.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001236
EMBL· GenBank· DDBJ
ACP11869.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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