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A4QGQ5 · IXTPA_CORGB

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site72Proton acceptor
Binding site72Mg2+ (UniProtKB | ChEBI)
Binding site73substrate
Binding site155-158substrate
Binding site182substrate
Binding site187-188substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      cgR_2413

Organism names

Accessions

  • Primary accession
    A4QGQ5

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000684181-206dITP/XTP pyrophosphatase

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    206
  • Mass (Da)
    22,010
  • Last updated
    2007-05-15 v1
  • MD5 Checksum
    A47C33DE4F567AEAAE71538B80DB3D76
MKLLLASNNAKKLKELQRILDQAGLDSVELLALRDVEAYDEPIEDGRTFADNAQIKARAGVAHTGIATIADDSGIAVEELNGMPGVLSARWSGAHGNDTANNELLLAQMEHVPDERRNAAFVSVCVLALPDGQEFVQEGRWEGQLLRGPKGENGFGYDPLFIPAEEIGGQGRSSAELSAEEKDALSHRGQALRGLVEKIAQVAAAS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP009044
EMBL· GenBank· DDBJ
BAF55421.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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