A3F5L3 · DES2_SORBI
- ProteinFatty acid desaturase DES2
- GeneDES2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids385 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Delta12 fatty acid desaturase converting palmitoleic acid (16:19) to hexadecadienoic acid (16:2(9,12)). No detectable Delta12linoleate desaturase activity. Involved in the biosynthesis of the aliphatic side chain of sorgoleone, a phytotoxic secondary metabolite playing a direct role in allelopathic interactions.
Pathway
Lipid metabolism; polyunsaturated fatty acid biosynthesis.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | oxidoreductase activity | |
Molecular Function | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water | |
Biological Process | unsaturated fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFatty acid desaturase DES2
- EC number
- Short namesSbDES2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Andropogonodae > Andropogoneae > Sorghinae > Sorghum
Accessions
- Primary accessionA3F5L3
Proteomes
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 65-85 | Helical | |||
Transmembrane | 89-109 | Helical | |||
Transmembrane | 122-142 | Helical | |||
Transmembrane | 185-205 | Helical | |||
Transmembrane | 231-251 | Helical | |||
Transmembrane | 254-274 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000434402 | 1-385 | Fatty acid desaturase DES2 | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-33 | Disordered | |||
Motif | 110-114 | Histidine box-1 | |||
Motif | 146-150 | Histidine box-2 | |||
Motif | 321-325 | Histidine box-3 | |||
Domain
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence similarities
Belongs to the fatty acid desaturase type 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)44,209
- Last updated2007-03-20 v1
- MD5 Checksum238D7347CCFD72463CA2E24EFF6FA8B8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EF206347 EMBL· GenBank· DDBJ | ABN49520.1 EMBL· GenBank· DDBJ | mRNA | ||
CM000763 EMBL· GenBank· DDBJ | EES05625.1 EMBL· GenBank· DDBJ | Genomic DNA |