A1B677 · MACB1_PARDP

Function

function

Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.

Features

Showing features for binding site.

166850100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site45-52ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiontransmembrane transporter activity
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Macrolide export ATP-binding/permease protein MacB 1/2
  • EC number

Gene names

    • Name
      macB1
    • Ordered locus names
      Pden_2937
    • Name
      macB2
    • Ordered locus names
      Pden_3444

Organism names

Accessions

  • Primary accession
    A1B677

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane294-314Helical
Transmembrane541-561Helical
Transmembrane598-618Helical
Transmembrane634-654Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002801691-668Macrolide export ATP-binding/permease protein MacB 1/2

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain9-247ABC transporter
Region230-257Disordered
Compositional bias239-255Pro residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    668
  • Mass (Da)
    69,941
  • Last updated
    2007-01-23 v1
  • Checksum
    D5BDAFF6AE0705B6
MAETGAPLIRLRGVGREYPSGEGVLRVLTDIDLDIGQGEFVAVMGASGSGKSTLMNILGCLDRPSSGSYRMDGREVARLGAGELAALRRETFGFIFQRYHLLSEMTALGNVEVPAIYRGLPADARRARARDLLERLGLGDRTGHRPGQLSGGQQQRVSIARALVNDARVILADEPTGALDSRSGDEVLGILERLNAEGRTVVIVTHDPRVAARAHRVVEIADGRIVADRRTGAPAADPGPGPAQAPQPAPQPAPVQAPVQARVQARAAVPVLGRLAEALRMALLSMRAHKLRSFLTMLGIIIGIASVVSVVALGEGSRRQVLQNIAGLGTNTLQIFPGRDFGDMRSGRVTTLVTADAAALARQPHVASVSPTVGTSATLRHGATEASAQISGVGEQYFDVAGVALTQGRGFDEADVAAMGQNVVIDENTRTSLFGDGPALGQVFMAGKVPLRVIGVAEAQNRGPGGSTSLTVYAPYTTVQARYLGSTSVSGLTLRVADDVDMALAEQMVADILTRRHGTRDFFIVNNDQIRQTITSTTQTLALLIAAIAVISLVVGGIGVMNIMLVSVTERIGEIGLRMAVGARRGDIRAQFLIEAVLVCVIGGIAGILAALGFGLAFERMSSDFTLVYSPLSMLAALASACAIGLAFGYLPAVNAAKLDPVKALQKG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias239-255Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000490
EMBL· GenBank· DDBJ
ABL71021.1
EMBL· GenBank· DDBJ
Genomic DNA
CP000490
EMBL· GenBank· DDBJ
ABL71515.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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