A1B677 · MACB1_PARDP
- ProteinMacrolide export ATP-binding/permease protein MacB 1/2
- GenemacB1; macB2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids668 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | transmembrane transporter activity | |
Biological Process | response to antibiotic |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMacrolide export ATP-binding/permease protein MacB 1/2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Paracoccaceae > Paracoccus
Accessions
- Primary accessionA1B677
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 294-314 | Helical | ||||
Sequence: FLTMLGIIIGIASVVSVVALG | ||||||
Transmembrane | 541-561 | Helical | ||||
Sequence: LALLIAAIAVISLVVGGIGVM | ||||||
Transmembrane | 598-618 | Helical | ||||
Sequence: LVCVIGGIAGILAALGFGLAF | ||||||
Transmembrane | 634-654 | Helical | ||||
Sequence: MLAALASACAIGLAFGYLPAV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000280169 | 1-668 | Macrolide export ATP-binding/permease protein MacB 1/2 | |||
Sequence: MAETGAPLIRLRGVGREYPSGEGVLRVLTDIDLDIGQGEFVAVMGASGSGKSTLMNILGCLDRPSSGSYRMDGREVARLGAGELAALRRETFGFIFQRYHLLSEMTALGNVEVPAIYRGLPADARRARARDLLERLGLGDRTGHRPGQLSGGQQQRVSIARALVNDARVILADEPTGALDSRSGDEVLGILERLNAEGRTVVIVTHDPRVAARAHRVVEIADGRIVADRRTGAPAADPGPGPAQAPQPAPQPAPVQAPVQARVQARAAVPVLGRLAEALRMALLSMRAHKLRSFLTMLGIIIGIASVVSVVALGEGSRRQVLQNIAGLGTNTLQIFPGRDFGDMRSGRVTTLVTADAAALARQPHVASVSPTVGTSATLRHGATEASAQISGVGEQYFDVAGVALTQGRGFDEADVAAMGQNVVIDENTRTSLFGDGPALGQVFMAGKVPLRVIGVAEAQNRGPGGSTSLTVYAPYTTVQARYLGSTSVSGLTLRVADDVDMALAEQMVADILTRRHGTRDFFIVNNDQIRQTITSTTQTLALLIAAIAVISLVVGGIGVMNIMLVSVTERIGEIGLRMAVGARRGDIRAQFLIEAVLVCVIGGIAGILAALGFGLAFERMSSDFTLVYSPLSMLAALASACAIGLAFGYLPAVNAAKLDPVKALQKG |
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-247 | ABC transporter | ||||
Sequence: IRLRGVGREYPSGEGVLRVLTDIDLDIGQGEFVAVMGASGSGKSTLMNILGCLDRPSSGSYRMDGREVARLGAGELAALRRETFGFIFQRYHLLSEMTALGNVEVPAIYRGLPADARRARARDLLERLGLGDRTGHRPGQLSGGQQQRVSIARALVNDARVILADEPTGALDSRSGDEVLGILERLNAEGRTVVIVTHDPRVAARAHRVVEIADGRIVADRRTGAPAADPGPGPAQAPQ | ||||||
Region | 230-257 | Disordered | ||||
Sequence: RTGAPAADPGPGPAQAPQPAPQPAPVQA | ||||||
Compositional bias | 239-255 | Pro residues | ||||
Sequence: GPGPAQAPQPAPQPAPV |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length668
- Mass (Da)69,941
- Last updated2007-01-23 v1
- ChecksumD5BDAFF6AE0705B6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 239-255 | Pro residues | ||||
Sequence: GPGPAQAPQPAPQPAPV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000490 EMBL· GenBank· DDBJ | ABL71021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP000490 EMBL· GenBank· DDBJ | ABL71515.1 EMBL· GenBank· DDBJ | Genomic DNA |