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A0AAJ1KWR0 · A0AAJ1KWR0_9ENTR

  • Protein
    Penicillin-binding protein 1B
  • Gene
    mrcB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site234Proton donor; for transglycosylase activity
Active site511Acyl-ester intermediate; for transpeptidase activity

GO annotations

AspectTerm
Cellular Componentmembrane
Cellular Componentpeptidoglycan-based cell wall
Molecular Functioncarboxypeptidase activity
Molecular Functionpenicillin binding
Molecular Functionpeptidoglycan glycosyltransferase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processproteolysis
Biological Processregulation of cell shape
Biological Processresponse to antibiotic

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Penicillin-binding protein 1B
  • Short names
    PBP-1b
    ; PBP1b
  • Alternative names
    • Murein polymerase

Gene names

    • Name
      mrcB
    • ORF names
      N5C89_23075
      , NP224_23860

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • BSI-KPN166
    • GD03918
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0AAJ1KWR0

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane65-87Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region1-61Disordered
Domain1-80Transglycosylase PBP1b N-terminal transmembrane
Domain114-198Bifunctional transglycosylase second
Domain208-380Glycosyl transferase family 51
Domain474-715Penicillin-binding protein transpeptidase
Compositional bias804-835Polar residues
Region804-851Disordered

Sequence similarities

In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    851
  • Mass (Da)
    94,915
  • Last updated
    2024-07-24 v1
  • MD5 Checksum
    B35584484A0A3D70B792DA6F3A3FC78E
MAGDDREPIGRKGRPSRPAKQKVTRRRVREEDYDDDYDDDDYEDEKPMPRKGKGKGGKPPRRKRAWLWLLIKVGVVCAVLIAAYGVYLDQKIRSRIDGKVWDLPAAVYGRMVNLEPDMQISKNEMVRLLNATQYRQVSAMTRPGEYTVQANSIEMIRRPFDFPDSKEGQVRARLTFNGDRLDTIENMDNNRQFGFFRLDPRLITMLQSANGEQRLFVKRNGFPDLLVDTLLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGASTLTQQLVKNLFLSSERSYWRKINEAYMALIVDARYSKDRILELYMNEVYLGQSGDNEIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASVYNPWRNPKLALERRNLVLRLLQQQQVIDQELYDMLSARPLGVQPRGGVISPQPAFMQMVRQELQAKLGDKVKDLSGVKIFTTFDSVAQDAAEKAATEGIPALKKQRKLPDLETAMVVVDRFTGEVRAMVGGAEPQFAGYNRAMQARRSIGSLAKPATYLTALSQPNQYRLNTWIADAPISIRLSNGQTWSPQNDDRRYSDSGKVMLVDALTRSMNVPTVNLGMALGLPAVVDTWTKLGAPKNQLNAVPSMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRSVIAEDGTVLYQSYPQAERAVPAQAAYMTLWTMQQVVQRGTGRQLGAKYPGLHLAGKTGTTNNNVDTWFAGIDGGQVTITWVGRDNNQPTKLYGASGAMSIYQRYLANQTPTPLVLTPPEDVVDMGVDGSGNFVCSGGMRSLPVWTTSPDALCRQGEQIQQQQLEQQQANNPFNQSGQQPQQQNQQQQPPKQEKSDGVAGWIKDMFGSN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias804-835Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAOCBF010000039
EMBL· GenBank· DDBJ
MDH0965721.1
EMBL· GenBank· DDBJ
Genomic DNA
CP102103
EMBL· GenBank· DDBJ
UWZ73193.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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