A0AAF0E525 · A0AAF0E525_9BASI

  • Protein
    Ribokinase
  • Gene
    RBK1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Activity regulation

Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.

Pathway

Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site13-15substrate
Binding site41-45substrate
Binding site148substrate
Binding site202ATP (UniProtKB | ChEBI)
Binding site240-245ATP (UniProtKB | ChEBI)
Binding site271K+ (UniProtKB | ChEBI)
Binding site273K+ (UniProtKB | ChEBI)
Binding site276-277ATP (UniProtKB | ChEBI)
Active site277Proton acceptor
Binding site277substrate
Binding site316K+ (UniProtKB | ChEBI)
Binding site319K+ (UniProtKB | ChEBI)
Binding site321K+ (UniProtKB | ChEBI)
Binding site325K+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionribokinase activity
Biological ProcessD-ribose catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribokinase
  • EC number
  • Short names
    RK

Gene names

    • Name
      RBK1
    • ORF names
      MOBT1_002381

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CBS 7876
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Ustilaginomycotina > Malasseziomycetes > Malasseziales > Malasseziaceae > Malassezia

Accessions

  • Primary accession
    A0AAF0E525

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias, repeat.

Type
IDPosition(s)Description
Domain11-328Carbohydrate kinase PfkB
Region359-427Disordered
Compositional bias372-404Polar residues
Repeat574-617WD

Sequence similarities

Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    786
  • Mass (Da)
    83,409
  • Last updated
    2024-05-29 v1
  • MD5 Checksum
    0809BEFBBFB1D83A29DC6B4B768E4CEE
MSEARCIVRSSVNIDETFQVPHIVRPGETISSSQMWSRPGGKGANVAAALVRHALTQGLAGVQVVMLGAVGEDAPWPLEHLRKHGVHVDDVHRSRDTPTGRAFIQISSADGENSIVLLKGANFAPVPALDDPARWLEAGATHLMLQNEIPLATTVAYARHARELKLRGSERRVCTIFNPSPMLSAEELKAFPWAGIDVLIVNEGEAADLRAALGGAPQGSPVEALAALEPLREIGWLVVTRGGDGFSAGVTIGSERVMLDMPASPPTRVVNTTGAGDTFAGYLVAGLMQAHNAREPSTKESAERILRTAGVAASMAVEADGAMESIPDAGAVQARAARVAPPTARARVVRGTVTPSRASRFFLPRTRSPPRTPETPALSITYSTPYAPTPSVRTPSTPDSDADTDAPPSPTLARKRARVAPRPVHTPRAPAPCAALWQLRTRPGRFRAPGAVPTAPFFARMATRVDYPYCLESQTPLGIASPLCVAYMHAARDADDPLPCLAAGDDEGRVHLLDTRIAADALDKPFVRHTTRPLVHGSLFALEWRSDDHVLAVGGSDYSVAAWDVQHEMCVARYDVHEGSARALAWDPHAGGRVLASGARDGAVYVWDLRQAAPARHIPRAHGAPRARRGARPAGVTALTYLDGGPLVSAGSEKAALKAWDLRARPVPVAQSADLSCGRAGNTRPHGVSSLAYGPRRARIYAACTDGAVYVVDAALSDVLRPDEPGALVHAAQRQNTLYARAALYDERYLAVGCNTGDVVVWDTAARGAPSGAVLPRAHLDKYVHG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias372-404Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP119938
EMBL· GenBank· DDBJ
WFD03687.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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