A0A9X4Y850 · A0A9X4Y850_9GAMM
- ProteinMembrane-bound lytic murein transglycosylase F
- GenemltF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids461 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
Catalytic activity
- Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 308 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Molecular Function | lytic transglycosylase activity | |
Biological Process | cell wall macromolecule catabolic process | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMembrane-bound lytic murein transglycosylase F
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Oceanospirillales > Halomonadaceae > Vreelandella
Accessions
- Primary accessionA0A9X4Y850
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell outer membrane ; Peripheral membrane protein
Note: Attached to the inner leaflet of the outer membrane.
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 37-261 | Solute-binding protein family 3/N-terminal | |||
Region | 262-461 | LT domain | |||
Domain
The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.
Sequence similarities
Belongs to the bacterial solute-binding protein 3 family.
In the C-terminal section; belongs to the transglycosylase Slt family.
In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length461
- Mass (Da)53,333
- Last updated2023-11-08 v1
- MD5 Checksum11424679AEA912CF684AB9D014BFDC70
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
WMEX01000001 EMBL· GenBank· DDBJ | MYL25176.1 EMBL· GenBank· DDBJ | Genomic DNA |