A0A9X0X0F5 · A0A9X0X0F5_9GAMM
- Protein3-ketoacyl-CoA thiolase
- GenefadA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids391 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Catalytic activity
- an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 95 | Acyl-thioester intermediate | |||
Active site | 347 | Proton acceptor | |||
Active site | 377 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | acetyl-CoA C-acyltransferase activity | |
Biological Process | fatty acid beta-oxidation | |
Biological Process | phenylacetate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-ketoacyl-CoA thiolase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Erwiniaceae > Erwinia
Accessions
- Primary accessionA0A9X0X0F5
Proteomes
Subcellular Location
Interaction
Subunit
Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 8-257 | Thiolase N-terminal | |||
Domain | 266-390 | Thiolase C-terminal | |||
Sequence similarities
Belongs to the thiolase-like superfamily. Thiolase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)41,665
- Last updated2023-11-08 v1
- MD5 Checksum702C0384DB32EC593FC0A82B1B715D67
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAEKEX010000001 EMBL· GenBank· DDBJ | MBK5418704.1 EMBL· GenBank· DDBJ | Genomic DNA |