A0A9P6GFB3 · A0A9P6GFB3_9PLEO

Function

function

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

111061002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site591-598ATP (UniProtKB | ChEBI)
Active site971
Active site1014

GO annotations

AspectTerm
Cellular Componentmitochondrial matrix
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Molecular Functionsingle-stranded DNA binding
Biological Processcellular response to oxidative stress
Biological Processchaperone-mediated protein complex assembly
Biological Processmitochondrion organization
Biological Processoxidation-dependent protein catabolic process
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease homolog, mitochondrial
  • EC number

Gene names

    • Name
      PIM1
    • ORF names
      PMIN01_07534

Organism names

  • Taxonomic identifier
  • Strain
    • Conio
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Dothideomycetes > Pleosporomycetidae > Pleosporales > Massarineae > Didymosphaeriaceae > Paraphaeosphaeria

Accessions

  • Primary accession
    A0A9P6GFB3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer or homoheptamer. Organized in a ring with a central cavity.

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region59-151Disordered
Compositional bias63-114Basic and acidic residues
Domain160-438Lon N-terminal
Region259-279Disordered
Coiled coil404-444
Region806-843Disordered
Compositional bias813-843Basic and acidic residues
Domain879-1065Lon proteolytic
Compositional bias1081-1096Basic and acidic residues
Region1081-1106Disordered

Sequence similarities

Belongs to the peptidase S16 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,106
  • Mass (Da)
    121,549
  • Last updated
    2023-09-13 v1
  • Checksum
    2022B9BFC6CF9D3F
MLHGQHLPWRAALRQASRSTVRAASSTVPSPYLPAQCTASFARCPRRYTSPPAALLFSRSFSTSMDRRKEQKPKTSPETSEEAKEEGEGEQNKQPKAVDDAEGVEAKSKAPEPIPRASDAKGSSAGDGAAGAGGDGGGKKRKQSDKSLVKPSIPDVYPQVMAIPIAKRPLFPGFYKAITIRNKEVGQAIADMVKRGQPYIGAFLLKDDEADKDVIDDPSEVYDVGTFCQVTSAFPIGADDNFAMTCVLYPHRRIKMTELKPAGANKPQESPSQGVEGADGASVVENTLGEAAPVQEPEAEQAKGDVVASFEESSADSTKAPHYYEATSFLKGKEVSIANVENLFEEPFDIKGNKVIPALVSEIVNTFKAVALLNPLFRDHISTFSVQTTMNVGEDPVKLADFAAAVAQADSHELQEALEELNVEQRLSKALIVLKKELMNAELQSKIVKDVENKITKKQREYWLLEQMKGIKRELGIESDGKDKLLEKFNDKASKLAMPEAVKKVFDEEISKLGHLEPNASEFNVTRNYLDWLTQLPWGQRSAENFGIKHAREVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSVARALNRQYYRFSVGGLSDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEVDKIGRGHNGDPSSALLELLDPEQNSSFLDHYLDVPVDLSKVLFVCTANMLDTIPRPLLDRMEIIELSGYVADEKIAIAERYLAPQAKIVNGLDKADVILEKEAIVELINKYCRESGVRNLKKQIEKVYRKSALKIVTDLGEEVFPESEALTEEGKTAQQEAEKDQTDVKETSENVEKETTEKPRVALQVPDSVHVSINKDNLKDYVGPPVFTSDRLYDVAPPGVAMGLAWTSMGGAALYVESILEKALSARSSPGLERTGSLKNVMKESTIVAYSFAKSLLAREFPKNKFFEHAQIHLHCPEGATPKDGPSAGITMATSLLGLALNTKVREGVAMTGELTVTGKVLRIGGLREKTVAARRAGATTVIFPADNMSDWLELPENIKDGIEGRPVSWYNEVFDLVFPGLDQDVSSKLWEKELKSKKGDRKRKEYKKREDDEEESGDDED

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias63-114Basic and acidic residues
Compositional bias813-843Basic and acidic residues
Compositional bias1081-1096Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WJXW01000007
EMBL· GenBank· DDBJ
KAF9734631.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help