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A0A9N9MU60 · A0A9N9MU60_9CUCU

Function

function

Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.

Catalytic activity

  • (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD+ = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD+ = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.232 (UniProtKB | ENZYME | Rhea)
  • 14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD+ = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H+
    This reaction proceeds in the forward direction.
  • 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H+ = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD+
    This reaction proceeds in the forward direction.
  • prostaglandin A1 + NAD+ = 15-oxo-prostaglandin A1 + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin E1 + NAD+ = 15-oxoprostaglandin E1 + NADH + H+
    This reaction proceeds in the forward direction.
  • prostaglandin E2 + NAD+ = 15-oxoprostaglandin E2 + NADH + H+
    This reaction proceeds in the forward direction.
    EC:1.1.1.141 (UniProtKB | ENZYME | Rhea)
  • resolvin D1 + NAD+ = 17-oxoresolvin D1 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D1 + NAD+ = 8-oxoresolvin D1 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D2 + NAD+ = 16-oxoresolvin D2 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin D2 + NAD+ = 7-oxoresolvin D2 + NADH + H+
    This reaction proceeds in the forward direction.
  • resolvin E1 + NAD+ = 18-oxo-resolvin E1 + NADH + H+
    This reaction proceeds in the forward direction.
  • lipoxin A4 + NAD+ = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H+
    This reaction proceeds in the forward direction.

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    15-hydroxyprostaglandin dehydrogenase [NAD(+)]
  • EC number
  • Alternative names
    • Eicosanoid/docosanoid dehydrogenase [NAD(+)]
    • Prostaglandin dehydrogenase 1

Gene names

    • ORF names
      CEUTPL_LOCUS11434

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Coleoptera > Polyphaga > Cucujiformia > Curculionidae > Ceutorhynchinae > Ceutorhynchus

Accessions

  • Primary accession
    A0A9N9MU60

Proteomes

Subcellular Location

Family & Domains

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    252
  • Mass (Da)
    27,196
  • Last updated
    2023-09-13 v1
  • MD5 Checksum
    1BD530ED2CC79A25DFDB0DD1D7C40FB7
MDLKGKVALVTGGASGHGREYCKELFKQGCKIAICDINADAGEDLLHQLSKNVKDRVIYIPCDVTDYMQFEEAFQTTISQLGGVDIVINNAAVMNDRLWELEVDVNLNGVIRGLLLAFRFLGKDRGGPGGIVVNAGSSCCKTPLVSLPVFTATKHAVAALTRCYGDAYHVNLTGIKVVALCPTPTESEIGGDPRKRILSGEYEQAWLRDTSCSVPVKPEKLGKALVEVIQSAKSGTSWLVSNDHPPKEIPLL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
OU892282
EMBL· GenBank· DDBJ
CAG9770992.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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