A0A9D2DCF2 · A0A9D2DCF2_9BACT

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site13Nucleophile
Binding site248[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site295Mg2+ (UniProtKB | ChEBI)
Binding site357Mg2+ (UniProtKB | ChEBI)
Binding site358Mg2+ (UniProtKB | ChEBI)
Binding site394[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site445[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site448[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processpurine nucleobase biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF
    • ORF names
      H9816_01220

Organism names

Accessions

  • Primary accession
    A0A9D2DCF2

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain13-232Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    470
  • Mass (Da)
    52,074
  • Last updated
    2023-05-03 v1
  • MD5 Checksum
    D14E4B0DB6D3C582B39F4B2AB84D8278
MAIYQDRTIHEECGVFGVFGVENAASLTYYGLHSLQHRGQEGCGIVSVDNRVFHRVKGEGLVTEVFNEDNIKTLTGNMAIGHVRYSTTGGGGIDNVQPFLFMHSTGDFALAHNGNLVNSVQLRTFLEERGSLFHSTSDSEIFAHLIKKETDNRDRIFPILEALNMVEGAFALLIETASKIYACRDKHGLRPLSIGRLGDGWVVSSETCAFEVVGAEFVRDVAPGEVVIIDANGLQSVDYSKFKHYNMCAMEYVYFARPDSDIENVNVHSFRKETGRMLYEEYPVDADIVVGVPDSSLSAAIGYSEASGIPYELGLIKNKYVGRTFIQPSQELREKGVRMKLSPVHSIVDGKRIVLVDDSIVRGTTSRRIVKMLRQAGAKEIHLRIASPAITSPCFYGVDISTYDELICAGKDGKERAREIIGADSLEWLSPEALFRAAGDRHELCIACFTGHYPTALYQSVYDANKDKKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DXCC01000004
EMBL· GenBank· DDBJ
HIZ14525.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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