A0A9D2DCC9 · A0A9D2DCC9_9BACT

Function

function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site11-16ATP (UniProtKB | ChEBI)
Binding site32AMP (UniProtKB | ChEBI)
Binding site37AMP (UniProtKB | ChEBI)
Binding site86-89AMP (UniProtKB | ChEBI)
Binding site93AMP (UniProtKB | ChEBI)
Binding site128ATP (UniProtKB | ChEBI)
Binding site134AMP (UniProtKB | ChEBI)
Binding site146AMP (UniProtKB | ChEBI)
Binding site174ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylate kinase activity
Molecular FunctionATP binding
Biological ProcessAMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylate kinase
  • EC number
  • Short names
    AK
  • Alternative names
    • ATP-AMP transphosphorylase
    • ATP:AMP phosphotransferase
    • Adenylate monophosphate kinase

Gene names

    • Name
      adk
    • ORF names
      H9816_00010

Organism names

Accessions

  • Primary accession
    A0A9D2DCC9

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region31-60NMP

Domain

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.

Sequence similarities

Belongs to the adenylate kinase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    21,645
  • Last updated
    2023-05-03 v1
  • MD5 Checksum
    FD726B6BF5A594115AD35F6A5FF421F9
MINIVLFGPPGAGKGTQADLLKEKYGLNHISTGEVIRDEIRRGTPRGLAVKEVIESGKLASDEMVLGIIGEYMASHADCKGNIFDGFPRTTRQAEEFDKMLAARSESVNVMVSLDVPDEELVKRLKLRAEYSGRADDADEKVIRNRIAVYKEQTAVVADYYARQEKYVAIDGVGTIEEIFARLCTVIDRYIDRK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DXCC01000001
EMBL· GenBank· DDBJ
HIZ14292.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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