A0A935K194 · A0A935K194_UNCIG

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      IPI19_00055

Organism names

  • Taxonomic identifier
  • Strain
    • Ega_18-Q3-R5-49_MAXAC.056
  • Taxonomic lineage
    Bacteria > Ignavibacteriota > Ignavibacteria > Ignavibacteriales

Accessions

  • Primary accession
    A0A935K194

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-35Helical
Transmembrane55-78Helical
Transmembrane87-109Helical
Transmembrane115-136Helical
Transmembrane143-165Helical
Transmembrane177-197Helical
Transmembrane230-246Helical
Transmembrane252-269Helical
Transmembrane276-295Helical
Transmembrane315-334Helical
Transmembrane341-362Helical
Transmembrane389-410Helical
Transmembrane422-444Helical
Transmembrane464-482Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-487Major facilitator superfamily (MFS) profile

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    500
  • Mass (Da)
    55,067
  • Last updated
    2023-02-22 v1
  • MD5 Checksum
    172FBEF724313C1AF5ECC77A9E44CC4E
MNTKELSLKPQPSSFLRWSALLLISLAMMGNYYIYDSISPLADLLKTQLGFSDSNIGLLNAIYSFPNIIMVLIGGLLIDRIGTKTSVLIFTALIMIGSIVTAITGNIWMMSAGRLIFGLGAESMIVAITTIIARWFKGKELSFAFGLNLTVARLGSFLALNSPSWGKSLYEYWQSPLWITVAGGVFAFICIGVYFFLDIYASKNYDLPKEGEQDAILLSDILRIKERTRWFLFAGISLVVIILTIVSPDNWAIYLIALIVAMLVLFLKAKSFSTSFWYITALCVTFYSAMFPFQTFAIKFFQEAHGTSREVGGNLSSILTLAAMIFTPLFGLLADKIGKRSLLMMFGSLLIIPVYLMMAYQFGKPEVMNESDFINITISFFDIDAAIPIYLILPMAMMGIAFSLIPAVMWPSVAIIVDSSKLGTAYGLMTMIQNIGLFGFNLLIGFANDYSGASATNPGGYTPGMWIFSTLGFLGLLFAFLLRKSETGPNAHGLEKGMTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JADJIH010000001
EMBL· GenBank· DDBJ
MBK7497521.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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