A0A8K0XCA6 · A0A8K0XCA6_9AGAM

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functiontransmembrane transporter activity

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      F5I97DRAFT_1814823

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FC_14
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Sclerodermatineae > Boletinellaceae > Phlebopus

Accessions

  • Primary accession
    A0A8K0XCA6

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane33-55Helical
Transmembrane75-97Helical
Transmembrane104-123Helical
Transmembrane129-149Helical
Transmembrane161-184Helical
Transmembrane196-215Helical
Transmembrane269-291Helical
Transmembrane311-332Helical
Transmembrane344-361Helical
Transmembrane373-397Helical
Transmembrane446-466Helical
Transmembrane543-565Helical

Keywords

  • Cellular component

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-471Major facilitator superfamily (MFS) profile

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    585
  • Mass (Da)
    64,461
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    0876CD66C5288AD00B8BD63969D579F0
MSCFSTSPKNVHPEVEDASNDRELQVISPARAFFIRSLALLCACSLSVGSHYASYTLGPLKSRLARELGTSNTEFSLLISAFSLNSTWTPLIGGIMASKLGTTITSIFATGVVFLGQVMLLLGETHENVRLMAFGLFVFGLGVSPLAVVQESIIVRFFKSHGLGVSMALGLVAGKCSSFVSARTSYPLSERFGRHAPFYASAALTGLSFLINIFYMSASKWLIHGSGTILEASEVRNEARRRAVYSLSEAKALEKVARKRSIKLRDIPLLGDVFWAYIGLNILCGMIWSPFTHLAANILQKRYNLTEDHAGAQASYLLAGSMILYPASGYLVDRLKHPQTIVRMFLLSSILTMLCYAWLAGPPQWTQTPFPGIISFASGIGFSPLLLVVIVPTLVPIQYVSTTLGVHKSLEQTGSTILQTLAGLWLDTPKQRFLDGDDAFSIQYLLNAFLLLNILQFISLFALGHVDRRRKGRDQLPYCPEDLVQNMQPDLSSPIAEDPSPPSVDPRKPLLTRPVAAISAYDLTAWDPRHGVCRRSEMRRGRIFAFLCAVLICSAWVLFLTIAWLRLRSKEDRGVTGDLHIVYVM

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEVFL010000009
EMBL· GenBank· DDBJ
KAH7883611.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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