A0A8K0TV57 · A0A8K0TV57_9AGAM

  • Protein
    Oxidized purine nucleoside triphosphate hydrolase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
    EC:3.6.1.56 (UniProtKB | ENZYME | Rhea)
  • 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+
    This reaction proceeds in the forward direction.
  • O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+
    This reaction proceeds in the forward direction.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
Molecular Functionmetal ion binding
Biological ProcessDNA protection

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxidized purine nucleoside triphosphate hydrolase
  • EC number
  • Alternative names
    • 2-hydroxy-dATP diphosphatase
    • 7,8-dihydro-8-oxoguanine triphosphatase
    • 8-oxo-dGTPase
    • Methylated purine nucleoside triphosphate hydrolase
    • Nucleoside diphosphate-linked moiety X motif 1

Gene names

    • ORF names
      F5I97DRAFT_1909638

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FC_14
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Basidiomycota > Agaricomycotina > Agaricomycetes > Agaricomycetidae > Boletales > Sclerodermatineae > Boletinellaceae > Phlebopus

Accessions

  • Primary accession
    A0A8K0TV57

Proteomes

Subcellular Location

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain30-157Nudix hydrolase

Sequence similarities

Belongs to the Nudix hydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    213
  • Mass (Da)
    23,507
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    74A751A08C51BCD0073CE0774E3A02FE
MDTEIPPGLEGNLSVFAEGGRETPWRSFEGRLFCTNAFIISDDKLLLGFKKRGFGAGLYNGFGGKVEPGETVLAAACRELEEESGINADLEHAGTLLFVNEGTELAFHIEIYSARSYTGTPVETDEMRPAWFSLSPESLSGTQTIHRDISALPSSSTDSSLPLIPYDKMWPDDIYWLPQLVDGQKFAGRADFRMESDGNLAMQRFWFGFVGST

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAEVFL010000012
EMBL· GenBank· DDBJ
KAH7882357.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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