A0A8I5KV08 · A0A8I5KV08_HUMAN
- ProteinPhosphoinositide phospholipase C
- GenePLCE1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1620 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | guanyl-nucleotide exchange factor activity | |
Molecular Function | phosphoric diester hydrolase activity | |
Biological Process | lipid catabolic process | |
Biological Process | small GTPase-mediated signal transduction |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoinositide phospholipase C
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8I5KV08
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Modified residue (large scale data) | 65 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 67 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 490 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 1096 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 1100 | PRIDE | Phosphothreonine | |||
Modified residue (large scale data) | 1151 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 1172 | PRIDE | Phosphoserine | |||
Modified residue (large scale data) | 1173 | PRIDE | Phosphoserine | |||
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 531-790 | Ras-GEF | |||
Region | 1053-1192 | Disordered | |||
Compositional bias | 1057-1084 | Polar residues | |||
Compositional bias | 1088-1125 | Basic and acidic residues | |||
Compositional bias | 1146-1192 | Polar residues | |||
Region | 1567-1620 | Disordered | |||
Compositional bias | 1579-1595 | Acidic residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,620
- Mass (Da)181,131
- Last updated2022-05-25 v1
- ChecksumFFA38ABE74FB97BF
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9P212 | PLCE1_HUMAN | PLCE1 | 2302 | ||
A0A6Q8PFG0 | A0A6Q8PFG0_HUMAN | PLCE1 | 1090 | ||
A0A6Q8PH04 | A0A6Q8PH04_HUMAN | PLCE1 | 1528 | ||
A0A6Q8PGT4 | A0A6Q8PGT4_HUMAN | PLCE1 | 1275 | ||
A0A6Q8PHN3 | A0A6Q8PHN3_HUMAN | PLCE1 | 1370 | ||
A0A6Q8PHP9 | A0A6Q8PHP9_HUMAN | PLCE1 | 809 | ||
B7ZM61 | B7ZM61_HUMAN | PLCE1 | 2286 | ||
A0A7I2PPM5 | A0A7I2PPM5_HUMAN | PLCE1 | 1960 | ||
A0A8I5KQ92 | A0A8I5KQ92_HUMAN | PLCE1 | 1137 | ||
A0A8I5KVG7 | A0A8I5KVG7_HUMAN | PLCE1 | 2231 | ||
A0A8I5KXT2 | A0A8I5KXT2_HUMAN | PLCE1 | 1978 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1057-1084 | Polar residues | |||
Compositional bias | 1088-1125 | Basic and acidic residues | |||
Compositional bias | 1146-1192 | Polar residues | |||
Compositional bias | 1579-1595 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL139118 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL139124 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL355341 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL365510 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL389885 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |