A0A8I3WB02 · A0A8I3WB02_CALJA

Function

function

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

GO annotations

AspectTerm
Cellular Componentcell-cell junction
Cellular ComponentCOP9 signalosome
Cellular Componentcytosol
Cellular Componentglutamatergic synapse
Cellular Componentlamellipodium
Cellular Componentruffle membrane
Cellular ComponentSchaffer collateral - CA1 synapse
Molecular Functioncalcium ion binding
Molecular Functionglutamate receptor binding
Molecular Functionneurotrophin TRKA receptor binding
Molecular Functionphosphatidylinositol phospholipase C activity
Molecular Functionreceptor tyrosine kinase binding
Biological Processcalcium-mediated signaling
Biological Processcell migration
Biological Processcellular response to epidermal growth factor stimulus
Biological Processepidermal growth factor receptor signaling pathway
Biological Processin utero embryonic development
Biological Processmodulation of chemical synaptic transmission
Biological Processphosphatidylinositol-mediated signaling
Biological Processphospholipid catabolic process
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of blood vessel endothelial cell migration
Biological Processpositive regulation of endothelial cell apoptotic process
Biological Processpositive regulation of release of sequestered calcium ion into cytosol
Biological Processpositive regulation of vascular endothelial cell proliferation
Biological Processrelease of sequestered calcium ion into cytosol
Biological ProcessT cell receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
  • EC number

Gene names

    • Name
      PLCG1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix

Accessions

  • Primary accession
    A0A8I3WB02

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue1259Phosphoserine
Modified residue1286Phosphoserine

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain27-142PH
Domain152-187EF-hand
Region522-544Disordered
Domain550-657SH2
Domain668-756SH2
Domain791-851SH3
Domain895-931PH
Domain953-1070PI-PLC Y-box
Domain1071-1194C2
Region1254-1287Disordered
Compositional bias1255-1271Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,315
  • Mass (Da)
    151,069
  • Last updated
    2022-05-25 v1
  • Checksum
    7CB869E92985EE4E
MAGAASPCANGCGPSAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGVDKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFVDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVDISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLSEGKMMERRKKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDIFPAKVSAAGVGWPEVGGRRTGNTLLKCRKVTDPLLHLPSLKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFEDFRISQEHLADHFDSRERR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
U3F1I8U3F1I8_CALJAPLCG11291
A0A5F4WJQ7A0A5F4WJQ7_CALJAPLCG11275

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1255-1271Polar residues

Keywords

Genome annotation databases

Similar Proteins

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