A0A8I3WB02 · A0A8I3WB02_CALJA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- GenePLCG1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1315 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Platyrrhini > Cebidae > Callitrichinae > Callithrix > Callithrix
Accessions
- Primary accessionA0A8I3WB02
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 1259 | Phosphoserine | |||
Modified residue | 1286 | Phosphoserine | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 27-142 | PH | |||
Domain | 152-187 | EF-hand | |||
Region | 522-544 | Disordered | |||
Domain | 550-657 | SH2 | |||
Domain | 668-756 | SH2 | |||
Domain | 791-851 | SH3 | |||
Domain | 895-931 | PH | |||
Domain | 953-1070 | PI-PLC Y-box | |||
Domain | 1071-1194 | C2 | |||
Region | 1254-1287 | Disordered | |||
Compositional bias | 1255-1271 | Polar residues | |||
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,315
- Mass (Da)151,069
- Last updated2022-05-25 v1
- Checksum7CB869E92985EE4E
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
U3F1I8 | U3F1I8_CALJA | PLCG1 | 1291 | ||
A0A5F4WJQ7 | A0A5F4WJQ7_CALJA | PLCG1 | 1275 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1255-1271 | Polar residues | |||
Keywords
- Technical term