A0A8C9X1P0 · A0A8C9X1P0_SANLU
- ProteinSterol carrier protein 2
- GeneLOC116045792
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids465 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Catalytic activity
- 3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoAThis reaction proceeds in the forward direction.
- 3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoAThis reaction proceeds in the forward direction.
- 7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)
- butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | peroxisome | |
Molecular Function | acyltransferase activity, transferring groups other than amino-acyl groups | |
Molecular Function | lipid binding | |
Biological Process | lipid transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSterol carrier protein 2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Perciformes > Percoidei > Percidae > Luciopercinae > Sander
Accessions
- Primary accessionA0A8C9X1P0
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length465
- Mass (Da)50,364
- Last updated2022-01-19 v1
- Checksum7F62A13F1B5291C3
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8C9X143 | A0A8C9X143_SANLU | LOC116045792 | 544 | ||
A0A8D0CNG8 | A0A8D0CNG8_SANLU | LOC116045792 | 524 | ||
A0A8C9X444 | A0A8C9X444_SANLU | LOC116045792 | 540 | ||
A0A8C9X4F3 | A0A8C9X4F3_SANLU | LOC116045792 | 531 | ||
A0A8C9X1I3 | A0A8C9X1I3_SANLU | LOC116045792 | 540 | ||
A0A8C9X163 | A0A8C9X163_SANLU | LOC116045792 | 538 |
Keywords
- Technical term