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A0A851BMG1 · A0A851BMG1_PICGY

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • sphing-4-enine 1-phosphate(in) + ATP + H2O = sphing-4-enine 1-phosphate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.
    EC:7.6.2.2 (UniProtKB | ENZYME | Rhea)
  • dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.
  • estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrial membrane
Cellular Componentplasma membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionefflux transmembrane transporter activity
Molecular Functionriboflavin transmembrane transporter activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Broad substrate specificity ATP-binding cassette transporter ABCG2
  • EC number
  • Alternative names
    • ATP-binding cassette sub-family G member 2
    • Urate exporter

Gene names

    • Name
      Abcg2_1
    • ORF names
      PICGYM_R10259

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-012-30
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Picathartidae > Picathartes

Accessions

  • Primary accession
    A0A851BMG1

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane364-384Helical
Transmembrane438-465Helical
Transmembrane477-498Helical
Transmembrane510-536Helical
Transmembrane609-627Helical

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer; disulfide-linked. The minimal functional unit is a homodimer, but the major oligomeric form in plasma membrane is a homotetramer with possibility of higher order oligomerization up to homododecamers.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-253ABC transporter

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    634
  • Mass (Da)
    70,253
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    94C14658BAF047CD98F686CFEF050551
GSVLTFHNICYRVKIKSGFLCFRKTTDKEVLRDVNGIMKPGLNAILGPTGSGKSSLLDILAARKDPHGLSGDILINGAPQPANFKCTSGYVVQDDVVMGTLTVRENLKFSAALRLPKSVKEEEKNERVNQIIKELGLSKVADSKVGTQFSRGVSGGERKRTNIGMELITDPAILFLDEPTTGLDASTANAVLLLLKRMSKQGKTIIFSIHQPRYSIFRLFDNLTLLAAGRLLYHGPAQHAVEYFQSIGYQCEPYNNPADFFLDIINGDSTAVALNKAGESNTAESTEERSEYDKTLAEQLAEKYSNSAYYRETKAHLESISSGNKKKTKGVFRQITYANSFLHQLKWVSKRTFKNMIGNPQASIAQVCVTAFLGLIVGAIFFGLEENSAGLQNRVGAMFFLTTNQCFSSISAIELFVVEKKIFIHEYISGYYRTSAYFIAKLMADLIPVRTMPSIIFTCIVYFMLGKYGLKPTVEAFFTMMFTLMMVSYTATSMALAIAAGQSVVAIANLLMTITFVFMIIFSGLLVNLTSVMSWLSWLKYFSIPRYGMTALQINELTGLNFCGSSNSTVHKVTNLVNVCVFICRACTGEEYLKSQGIDASPWGLWQNHLALACMTLILLTIAYLKLHFMKKFS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue634

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WEKY01050112
EMBL· GenBank· DDBJ
NWI45840.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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