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A0A836I141 · A0A836I141_9TRYP

Function

function

Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J-DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological Processbase J metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thymine dioxygenase JBP1
  • EC number
  • Alternative names
    • J-binding protein 1
    • Thymidine hydroxylase JBP1

Gene names

    • ORF names
      LSCM4_06841

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LSCM4
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    A0A836I141

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Monomer. Binds to DNA as a monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain107-2632OGFeDO JBP1/TET oxygenase
Domain396-559Thymine dioxygenase JBP1 DNA-binding

Sequence similarities

Belongs to the TET family. JBP1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    814
  • Mass (Da)
    91,704
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    2380E5851B7F86A100D325C0C839931B
MESDAKKVRLDIFNFPSGKDKRTPEDVAESYAEAVKSHPFYDNVHSVIDFYDSGTIRDGRGQVVGVVLRKAVPEYAASMAAELLISAAVRTSLRSTMFGGESPLSGIAGYFDYRGSPVELKSRKTSFTYEHEAEWPAVFPVVDYVSEIYRHVAPEQWKAQNDAIPDVVRIHGTPFSTLTINSRFRTASHTDVGDFDGGYSCIACIDGQFKGLALSFDDFHINVLLQPRDVLIFDSHHFHSNTEVEVSCSGEDWKRLTCVFYYRAALGEPSSYAEYRRRLEKSRQDASFTPVVSKVRVKENGTNLNRRSPVHPITPSPFSVPMLAHRLQHCASAAQIVHNAMTTVGSRLAEVVFGEPLSTSDGIPLREESEKLKANADSAAKPPSHLGGFSETNLMVSTAVEKKKYLNSEFLSNCISAQLLSMWKQARAKWLELVDKEWEHMLTLNPERKDYVWKNQSEMNAAFFDLCEVGKQVMLGLLGKEAALPKEEQAFWTMYAVHLSAACVEELHMPQEAMSLRKLNVKLKDFNFGGTRYFKDMPPEEQQRRMERKQRIEDARRHGMLSGAHEKRESWLTNDSFDYQTEDCAIDYAGHNWVLPARHAEEITKNVRAGELPTREGVVRILVVLPNSKSQADSVNCNLEMPDDVRCSSEWMRLMSSPAVHRVLAAAQRNLQLPDSFTQDSIHIDFAFHSTLPTDVYDFVVLQHVLSCIPDDALASSYIKRALALCSGCLFVAETDVQCRQYFTLKPSIRCDYDAVAPLFFQQLHRVSYGTKMARVRTKEELEALITTVCHARCKLQGSPLNTTVHVVSPDVPQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAFHLR010000009
EMBL· GenBank· DDBJ
KAG5486133.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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