Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A829GPX3 · A0A829GPX3_LACPA

Function

function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site11substrate
Binding site11-12ATP (UniProtKB | ChEBI)
Binding site19ATP (UniProtKB | ChEBI)
Site19Transition state stabilizer
Binding site43substrate
Binding site76substrate
Binding site90substrate
Binding site91-93ATP (UniProtKB | ChEBI)
Binding site101ATP (UniProtKB | ChEBI)
Binding site126-132ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionpantetheine-phosphate adenylyltransferase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphopantetheine adenylyltransferase
  • EC number
  • Alternative names
    • Dephospho-CoA pyrophosphorylase
    • Pantetheine-phosphate adenylyltransferase
      (PPAT
      )

Gene names

    • Name
      coaD
    • ORF names
      Lpl14_15193

Organism names

Accessions

  • Primary accession
    A0A829GPX3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-136Cytidyltransferase-like

Sequence similarities

Belongs to the bacterial CoaD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    18,129
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    363EFE7C2241653750B2292BD01448B2
MTKKIAVFPGSFDPFTNGHLDTVKRASRLFDEVVVAAMTNTSKKPLFSSEEKLALISESTAGLPNVKAMAAPKRLTVEFARSIGAQFMIRGIRNVADFGYEADIATVNHDLDPEIETVFLLADKQYDALSSTIIKEVAAFGGDVHRFVPAPVEAALYAKLGDAHQTK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ANKB01000128
EMBL· GenBank· DDBJ
EPC62290.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help