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A0A7X7I9D7 · A0A7X7I9D7_9BACT

  • Protein
    Phosphoenolpyruvate carboxykinase [GTP]
  • Gene
    pckG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site70substrate
Binding site212-214substrate
Binding site221Mn2+ (UniProtKB | ChEBI)
Binding site241Mn2+ (UniProtKB | ChEBI)
Binding site263substrate
Binding site264-269GTP (UniProtKB | ChEBI)
Active site265
Binding site288Mn2+ (UniProtKB | ChEBI)
Binding site379-381substrate
Binding site381GTP (UniProtKB | ChEBI)
Binding site412GTP (UniProtKB | ChEBI)
Binding site508-511GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      GX640_22080

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • AS06rmzACSIP_543
  • Taxonomic lineage
    Bacteria > Fibrobacterota > Fibrobacteria > Fibrobacterales > Fibrobacteraceae > Fibrobacter

Accessions

  • Primary accession
    A0A7X7I9D7

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-233Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain237-597Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    600
  • Mass (Da)
    65,805
  • Last updated
    2021-06-02 v1
  • MD5 Checksum
    B7EDD6DDB22D1AC3EBFBBA14618E4639
MSSKHEKLNKWVDEMAALCQPDSVEWCDGSKAEYDRMIKIMVDGKLAKPLNEKKLPGCVLFRSDPSDVARVENRTYIASKTKEAAGPTNNWIDPEELKTIMKGLYKGCMKGRTMYVIPFSMGPIGSNIAKIGVELTDSPYVVANMHIMTRVGSKVLDVLGTDGEFIPCLHSVGKPLAEGESDNGMWPCAPLDKKYISHFPEERTIWSYGSGYGGNALLGKKCLALRIASVIARDEGWLAEHMLILGITNPEGVKKYVAAAFPSACGKTNLAMLIPTIPGWKVETIGDDIAWMKFGKDGRLYAINPEAGFFGVAPGTSMDSNPNAMKSISKNTIYTNVALTADGDVWWEGIGYDAPGKLIDWKGNEWDKATAKEPAAHPNARFTAPAANCPAVAPEWEDPAGVPISAILFGGRRPSTVPLVHQAFNWEHGVFMGSIVGSEVTAAALDLKAGTVRRDPFAMLPFCGYHMGDYFAHWLKIGTKTDADKLPKIFFVNWFRKSPDGKWLWPGYGENSRVLKWIFERVDGKADADKSAIGYIPKSSDIDTTGLNVPAADMAELLKVDSSEWLKEVESIKEHYAKFGDKLPKKLSDELAALEARLKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAZBH010001028
EMBL· GenBank· DDBJ
NLE02563.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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