A0A7L0SFM2 · A0A7L0SFM2_PODPO
- ProteinEctonucleoside triphosphate diphosphohydrolase 1
- GeneEntpd1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids503 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides. By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow.
Catalytic activity
- ITP + 2 H2O = IMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- UTP + 2 H2O = UMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- ADP + H2O = AMP + phosphate + H+This reaction proceeds in the forward direction.
- ATP + 2 H2O = AMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- ATP + H2O = ADP + phosphate + H+This reaction proceeds in the forward direction.
- CDP + H2O = CMP + phosphate + H+This reaction proceeds in the forward direction.
- CTP + 2 H2O = CMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- CTP + H2O = CDP + phosphate + H+This reaction proceeds in the forward direction.
- GDP + H2O = GMP + phosphate + H+This reaction proceeds in the forward direction.
- GTP + 2 H2O = GMP + 2 phosphate + 2 H+This reaction proceeds in the forward direction.
- GTP + H2O = GDP + phosphate + H+This reaction proceeds in the forward direction.
- IDP + H2O = IMP + phosphate + H+This reaction proceeds in the forward direction.
- ITP + H2O = IDP + phosphate + H+This reaction proceeds in the forward direction.
- UDP + H2O = UMP + phosphate + H+This reaction proceeds in the forward direction.
- UTP + H2O = UDP + phosphate + H+This reaction proceeds in the forward direction.
- a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate + H+This reaction proceeds in the forward direction.
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+This reaction proceeds in the forward direction.
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 159 | Proton acceptor | |||
Binding site | 206-210 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | hydrolase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEctonucleoside triphosphate diphosphohydrolase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Mirandornithes > Podicipediformes > Podicipedidae > Podilymbus
Accessions
- Primary accessionA0A7L0SFM2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 470-492 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5029616549 | 22-503 | Ectonucleoside triphosphate diphosphohydrolase 1 | ||
Keywords
- PTM
Interaction
Subunit
Homodimer; disulfide-linked.
Structure
Sequence
- Sequence statusFragment
- Length503
- Mass (Da)56,239
- Last updated2021-04-07 v1
- Checksum5603BAF395385A03
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 503 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VXAO01000008 EMBL· GenBank· DDBJ | NXL41156.1 EMBL· GenBank· DDBJ | Genomic DNA |