A0A7K6H475 · A0A7K6H475_9PASS
- ProteinMacrophage-expressed gene 1 protein
- GeneMpeg1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids720 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.
Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8+ T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | phagocytic vesicle membrane | |
Biological Process | adaptive immune response | |
Biological Process | defense response to bacterium |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMacrophage-expressed gene 1 protein
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Meliphagoidea > Maluridae > Malurus
Accessions
- Primary accessionA0A7K6H475
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, phagosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 655-676 | Helical | ||||
Sequence: VAGVTAAVLAGLATVLGTAWYG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MAGVLWGVLLAWAPLAWLARA | ||||||
Chain | PRO_5029472236 | 22-720 | Macrophage-expressed gene 1 protein | |||
Sequence: GQSQELSSSSGFGVCGRSLKLSRLEVLPGGGWDNLRNLDMGRVINLGYSQCKTTEDGSYIIPDEIFTIPRKQSHLDINSEIIESWKDYQSVTSASINLELSLFSAINGKFSSDFHRTKTQQVRDRSVTTRVQVRNLVYTAKVDPEAALDEAFKKQLLTIASHLENNQTQMADFLAEVLVLNYGTHAITSVDAGAALVQEDQIKATFLKDSWATRSAITAAAGATFHSIVSLGMKESVESHAGSDFTKRYLENRTNSRVESIGGTPFYPGITLKAWQERIQNQLVALDRAGLPLHFFIKPGTVPELPAPTVRRVARRVELAIHRYYTFNTAPGCTDPSSPNFNFHANTDDGSCQGTGANFTFGGLFQECADLAGPDTGALCRALEQKNPLTGAFSCPAAYTPVLLGVQEREEGHSHLECHNKCVLGIFCHRECQDVFWLSRVRFSAYWCAASGPVAPNSGYLFGGLFSTHSANPLTRAQSCPSGYFPLRLFGELSVCVSQDYEAGAEYAVPFGGFFSCQAGNPLAGRHRGTAGDPHAKGCPPGFSQHLALISDSCQVQFCVRAGFLTGGSLPPARLPPFTRRPANLPAVDTLLVRDGASTWVRDGQSHVWRLARPDEAKHVVEMVGGRGLSGGQVAGVTAAVLAGLATVLGTAWYGRRRYRARGYRSLGTGDDTATAGPEPSTVLSVGEGYQQEPEGTVP |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 19-349 | MACPF | ||||
Sequence: ARAGQSQELSSSSGFGVCGRSLKLSRLEVLPGGGWDNLRNLDMGRVINLGYSQCKTTEDGSYIIPDEIFTIPRKQSHLDINSEIIESWKDYQSVTSASINLELSLFSAINGKFSSDFHRTKTQQVRDRSVTTRVQVRNLVYTAKVDPEAALDEAFKKQLLTIASHLENNQTQMADFLAEVLVLNYGTHAITSVDAGAALVQEDQIKATFLKDSWATRSAITAAAGATFHSIVSLGMKESVESHAGSDFTKRYLENRTNSRVESIGGTPFYPGITLKAWQERIQNQLVALDRAGLPLHFFIKPGTVPELPAPTVRRVARRVELAIHRYYTFN | ||||||
Region | 686-720 | Disordered | ||||
Sequence: RSLGTGDDTATAGPEPSTVLSVGEGYQQEPEGTVP |
Sequence similarities
Belongs to the MPEG1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length720
- Mass (Da)77,774
- Last updated2021-04-07 v1
- Checksum8EB0F47F5D6A5370
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Non-terminal residue | 720 | |||||
Sequence: P |
Keywords
- Technical term