A0A7K6H475 · A0A7K6H475_9PASS

Function

function

Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide.
Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8+ T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

AspectTerm
Cellular Componentphagocytic vesicle membrane
Biological Processadaptive immune response
Biological Processdefense response to bacterium

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Macrophage-expressed gene 1 protein
  • Alternative names
    • Perforin-2

Gene names

    • Name
      Mpeg1
    • ORF names
      MALELE_R13366

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-029-44
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Meliphagoidea > Maluridae > Malurus

Accessions

  • Primary accession
    A0A7K6H475

Proteomes

Subcellular Location

Cytoplasmic vesicle, phagosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane655-676Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_502947223622-720Macrophage-expressed gene 1 protein

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain19-349MACPF
Region686-720Disordered

Sequence similarities

Belongs to the MPEG1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    720
  • Mass (Da)
    77,774
  • Last updated
    2021-04-07 v1
  • Checksum
    8EB0F47F5D6A5370
MAGVLWGVLLAWAPLAWLARAGQSQELSSSSGFGVCGRSLKLSRLEVLPGGGWDNLRNLDMGRVINLGYSQCKTTEDGSYIIPDEIFTIPRKQSHLDINSEIIESWKDYQSVTSASINLELSLFSAINGKFSSDFHRTKTQQVRDRSVTTRVQVRNLVYTAKVDPEAALDEAFKKQLLTIASHLENNQTQMADFLAEVLVLNYGTHAITSVDAGAALVQEDQIKATFLKDSWATRSAITAAAGATFHSIVSLGMKESVESHAGSDFTKRYLENRTNSRVESIGGTPFYPGITLKAWQERIQNQLVALDRAGLPLHFFIKPGTVPELPAPTVRRVARRVELAIHRYYTFNTAPGCTDPSSPNFNFHANTDDGSCQGTGANFTFGGLFQECADLAGPDTGALCRALEQKNPLTGAFSCPAAYTPVLLGVQEREEGHSHLECHNKCVLGIFCHRECQDVFWLSRVRFSAYWCAASGPVAPNSGYLFGGLFSTHSANPLTRAQSCPSGYFPLRLFGELSVCVSQDYEAGAEYAVPFGGFFSCQAGNPLAGRHRGTAGDPHAKGCPPGFSQHLALISDSCQVQFCVRAGFLTGGSLPPARLPPFTRRPANLPAVDTLLVRDGASTWVRDGQSHVWRLARPDEAKHVVEMVGGRGLSGGQVAGVTAAVLAGLATVLGTAWYGRRRYRARGYRSLGTGDDTATAGPEPSTVLSVGEGYQQEPEGTVP

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue720

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VZRP01019842
EMBL· GenBank· DDBJ
NWV70399.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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