A0A7J7U5V1 · A0A7J7U5V1_MYOMY
- ProteinOrnithine decarboxylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids462 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Catalytic activity
- L-ornithine + H+ = putrescine + CO2
Cofactor
Pathway
Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 360 | Proton donor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ornithine decarboxylase activity | |
Biological Process | putrescine biosynthetic process from ornithine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOrnithine decarboxylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Myotis
Accessions
- Primary accessionA0A7J7U5V1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 69 | N6-(pyridoxal phosphate)lysine | |||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 45-281 | Orn/DAP/Arg decarboxylase 2 N-terminal | |||
Domain | 282-387 | Orn/DAP/Arg decarboxylase 2 C-terminal | |||
Sequence similarities
Belongs to the Orn/Lys/Arg decarboxylase class-II family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length462
- Mass (Da)51,154
- Last updated2021-04-07 v1
- MD5 Checksum35AF063C615E0833E084063E3D81E897
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J7U623 | A0A7J7U623_MYOMY | mMyoMyo1_014308 | 464 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JABWUV010000014 EMBL· GenBank· DDBJ | KAF6308263.1 EMBL· GenBank· DDBJ | Genomic DNA |