Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A7J7C9J6 · A0A7J7C9J6_TRIWF

Function

function

IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site133For GATase activity
Active site133Nucleophile
Binding site133L-glutamine (UniProtKB | ChEBI); covalent
Active site238
Active site238For GATase activity
Active site240
Active site240For GATase activity
Active site281
Binding site368substrate
Active site439
Binding site504substrate

GO annotations

AspectTerm
Cellular Componentchloroplast
Molecular Functionglutaminase activity
Molecular Functionimidazoleglycerol-phosphate synthase activity
Molecular Functionoxo-acid-lyase activity
Biological Processglutamine metabolic process
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Imidazole glycerol phosphate synthase hisHF

Including 2 domains:

  • Recommended name
    Glutaminase
  • EC number
  • Recommended name
    Cyclase

Gene names

    • ORF names
      HS088_TW19G00128

Organism names

  • Taxonomic identifier
  • Strain
    • cv. XIE 37
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Celastrales > Celastraceae > Tripterygium

Accessions

  • Primary accession
    A0A7J7C9J6

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain58-254Glutamine amidotransferase
Region400-401PRFAR binding
Region437-439PRFAR binding
Region509-510PRFAR binding
Region535-536PRFAR binding
Region558-559PRFAR binding

Sequence similarities

Belongs to the HisA/HisF family.
In the C-terminal section; belongs to the HisA/HisF family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    584
  • Mass (Da)
    63,678
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    FA4AE03128AD4DAC33201AA1D776336B
MEAAPFGSSTATRPFSSASSSSLLFLRRNKSHKNYLQFKSPKSVSVRASSAGNSVVTLLDYGAGNVRSVRNAIRHLGFDIKDVQTPEDILNADRLIFPGVGAFALAMDVLNKTGMAEALCTYIDNDRPFLGICLGLQLLFESSEENGPVNGLGLIPGVVGRFDSSNGFRVPHIGWNALQIVKDSEILDDIGNRHVYFVHSYRAMPSDDNKEWVSSVCNYGDNFIASVRRGNVHAVQFHPEKSGDTGLSILRRFLYPKSSFTKKPVEVKASKLAKRVIACLDVRANDTGDLVVTKGDQYDVREHTKENEVRNLGKPVELAGQYYKDGADEVSFLNITGFRDFPLGDLPMLQVLRYTSENVFVPLTVGGGIRDFTDANGRHYSSLEVASEYFRSGADKISIGSDAVYAAEEYLKTGVKTGKSSLEQISRVYGNQAVVVSIDPRRVYCNSPNDVEFKAVRLSKPGPNGEEYAWYQCTVNGGREGRPIGAYELAKAVEELGAGEIMLNCIDCDGQGKGFDIDLIKLVSDAVSIPVIASSGAGAAEHFSEVFMKTNASAALAAGIFHRKEVPIQSVKEHLLKEGIEVRT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAARO010000019
EMBL· GenBank· DDBJ
KAF5730537.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help