A0A7C8BRN5 · A0A7C8BRN5_9ACTN

  • Protein
    dITP/XTP pyrophosphatase
  • Gene
    rdgB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8-13substrate
Active site75Proton acceptor
Binding site75Mg2+ (UniProtKB | ChEBI)
Binding site76substrate
Binding site158-161substrate
Binding site183substrate
Binding site188-189substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      F8D48_06120

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • DSM 29508
  • Taxonomic lineage
    Bacteria > Bacillati > Actinomycetota > Coriobacteriia > Eggerthellales > Eggerthellaceae > Adlercreutzia

Accessions

  • Primary accession
    A0A7C8BRN5

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    204
  • Mass (Da)
    21,124
  • Last updated
    2021-02-10 v1
  • MD5 Checksum
    E37C1F06A81748C09F6F6BD77702994A
MKTVVIATNNAHKVSEIRSALNFEGWEFKTLAEAGLVSAPVEDADSFEGNARIKARAAAEAVRAAGLTAAVLADDSGLAVDALDGAPGVYSSRYAGADGDDGANNAKLLAELAAVPDGERTARFVCTLVFMDEDGTETVARGTIEGAIGREARGSEGFGYDPLFIPDAFGGALTLAEVPQARKNAVSHRGNALRALRDSLASDR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
WAJS01000015
EMBL· GenBank· DDBJ
KAB1648585.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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