A0A6U0QSA6 · A0A6U0QSA6_9VIRI
- ProteinAlpha-ketoglutarate-dependent dioxygenase FTO
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids478 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- N6-methyladenosine in U6 snRNA + 2-oxoglutarate + O2 = adenosine in U6 snRNA + formaldehyde + succinate + CO2
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O2 = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO2
- a 5'-end (N7-methyl 5'-triphosphoguanosine)-(N6,2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O2 = a 5'-end (N7-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO2
- an N1-methyladenosine in tRNA + 2-oxoglutarate + O2 = an adenosine in tRNA + formaldehyde + succinate + CO2
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Molecular Function | broad specificity oxidative DNA demethylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidative RNA demethylase activity | |
Biological Process | DNA alkylation repair | |
Biological Process | regulation of multicellular organism growth | |
Biological Process | RNA repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAlpha-ketoglutarate-dependent dioxygenase FTO
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Prasinodermophyta > Prasinodermophyceae > Prasinodermales > Prasinodermaceae > Prasinoderma
Accessions
- Primary accessionA0A6U0QSA6
Subcellular Location
Interaction
Subunit
Monomer. May also exist as homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-223 | Alpha-ketoglutarate-dependent dioxygenase FTO catalytic | |||
Region | 444-478 | Disordered | |||
Compositional bias | 460-478 | Basic residues | |||
Sequence similarities
Belongs to the alkB family.
Belongs to the fto family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length478
- Mass (Da)51,285
- Last updated2020-12-02 v1
- MD5 Checksum41A51C180FD6632365FB71F028351A0A
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 460-478 | Basic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HBDZ01015534 EMBL· GenBank· DDBJ | CAD8250468.1 EMBL· GenBank· DDBJ | Transcribed RNA | ||
HBDZ01015535 EMBL· GenBank· DDBJ | CAD8250469.1 EMBL· GenBank· DDBJ | Transcribed RNA |