Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A6U0QSA6 · A0A6U0QSA6_9VIRI

  • Protein
    Alpha-ketoglutarate-dependent dioxygenase FTO
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Molecular Functionbroad specificity oxidative DNA demethylase activity
Molecular Functionmetal ion binding
Molecular Functionoxidative RNA demethylase activity
Biological ProcessDNA alkylation repair
Biological Processregulation of multicellular organism growth
Biological ProcessRNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-ketoglutarate-dependent dioxygenase FTO
  • EC number
  • Alternative names
    • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
    • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
    • mRNA N(6)-methyladenosine demethylase FTO
    • tRNA N1-methyl adenine demethylase FTO

Gene names

    • ORF names
      PCOL08062_LOCUS12000
      , PCOL08062_LOCUS12001

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • CCMP1413
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Prasinodermophyta > Prasinodermophyceae > Prasinodermales > Prasinodermaceae > Prasinoderma

Accessions

  • Primary accession
    A0A6U0QSA6

Subcellular Location

Keywords

Interaction

Subunit

Monomer. May also exist as homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain3-223Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Region444-478Disordered
Compositional bias460-478Basic residues

Sequence similarities

Belongs to the alkB family.
Belongs to the fto family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    51,285
  • Last updated
    2020-12-02 v1
  • MD5 Checksum
    41A51C180FD6632365FB71F028351A0A
MVSAGSKGGVTKTSVTRMLIGEAGITYKYLGLRLFAHPWSGEALAGAGVGAEGAEALRTIGELNAWLSRRAAEHCVELRGEGGGGGRADFNLTLINRMVNASEKSLRPEPLYELGPASVSWHADSGLVDFSTISVFHNVRALDEDEGIGEQEAGEGGACGWRVALRVSGEPEGKRTPAIVAELPSDSCYHLCDDFNHFHEHAVLASHTPNTVRHSSTHRVAREEGGCWGYLHEKATETLGADVVGVEDSQARGAADEGAETSVAEAEVAPLLSNLKQLKAEQELLSELESEWLRQWWIQGALNARQLPWWHQPIKRMRAWHARLEARTLAVVKALARTARGGTGAVPKEHTAACGVLASALESRALKRRAWQERESDSQWATMPREARPIPCPLQGEAAARELLQAVRAVRSLLAERSAGEGASKKTVRAAKAGQSNWLALSKSMAGGGVPPAGGVAKAKGAKHAKKRHKKHKHRPAG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias460-478Basic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HBDZ01015534
EMBL· GenBank· DDBJ
CAD8250468.1
EMBL· GenBank· DDBJ
Transcribed RNA
HBDZ01015535
EMBL· GenBank· DDBJ
CAD8250469.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help